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Breakpoint cluster region rearrangement in CML |
| Test |
Breakpoint cluster region rearrangement in CML |
| Indication |
This test characterize and monitor chronic myelogenous leukemia (CML) |
| Physiology |
CML is characterised by reciprocal translocation between chromosomes 9 and 22 producing the philadelphia chromosome. The translocation involves a gene rearrangement of the breakpoint cluster region gene located on chromosome 22 with c-abl oncogene on chromosome 9. |
| Normal Range |
Philadelphia chromosome has been found in 20% to 25% of patients with acute lymphoblastic leukemia and 2% of patients with acute myelogenous leukemia (AML) |
| Interpretation |
Chromosome analysis, Polymerase chain reaction |
| Sample |
No rearrangement observed |
| Test Method |
Nucleic acid technology |
| Related Tests |
Blood, bone marrow |
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