You've probably dreamed of the perfect world where gorging on chocolate cake and juicy beef roast will leave your "bad cholesterol" levels untouched? That 'dream' can now be reality with synthetic high-density lipoprotein (HDL).
Scientists at Northwestern University have designed synthetic HDL, the "good" cholesterol, which could help fight chronically high cholesterol levels and the resulting deadly heart disease.
The researchers have shown that their nanoparticle version of the is a promising new weapon to bind cholesterol irreversibly.
The synthetic HDL, based on gold nanoparticles, is similar in size to HDL and mimics HDL's general surface composition.
"We have designed and built a cholesterol sponge. The synthetic HDL features the basics of what a great cholesterol drug should be," said Chad A. Mirkin, George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences, who led the study with Shad Thaxton, M.D., assistant professor of urology in Northwestern's Feinberg School of Medicine
He added: "Drugs that lower the bad cholesterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL. I've taken niacin to try and raise my HDL, but the side effects are bad so I stopped. We are hopeful that our synthetic HDL will one day help fill this gap in useful therapeutics."
To create synthetic HDL the researchers started with a gold nanoparticle as the core, which was then layered on a lipid that attaches to the gold surface, followed by another lipid and last a protein, called APOA1.
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Substituting a synthetic HDL for niacin is a losing proposition. A good place to learn all about niacin therapy is at the website www.cholesterolscore.com .
It seems that therapeutic doses of niacin, which have been used & studied since the 1950's, have done much more than what statin drugs like Crestor promise. From lowering LDL to improving C-reactive protein levels, to lowering triglycerides, to enlarging lipid particle size, to increasing longevity, no other medication has been found to be as effective as niacin. Niacin, though, is less expensive than aspirin.
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