Bacterial Protein may Help Protect Against Several Skin Disease

A protein secreted by the most common bacteria on human skin protects against reactive oxidative stress, which is a contributing factor to several skin diseases.

Highlights

The most common bacteria on the human skin may help treat several skin diseases.
The acne-causing bacteria secretes a protein that protects against oxidative stress.
A bacterial protein called RoxP protects against oxidative stress, which is a contributing factor in several skin diseases.

Bacteria play an important role by benefiting human health in many ways. Now, new research by scientists from Lund University in Sweden, shows that bacteria found in the skin may help protect against a variety of diseases. //

Bacterial Protein Protects Against Skin Disease

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In mice, although muscle cells did not reduce in size or number lacking a protective antioxidant protein, they were weaker than normal muscle cells.

‘Acne-causing bacteria secretes a protein called RoxP, which protects the against oxidative stress.’

A protein secreted by the most common bacteria on human skin protects against reactive oxidative stress, which is a contributing factor to several skin diseases. The acne-causing bacterium is called Propionibacterium acnes.

Lead researcher Rolf Lood from Lund University in Sweden, said,"The name originates from the fact that the bacterium was first discovered on a patient with severe acne. But whether it causes acne is uncertain - it may have been present merely because it is so common."

Rolf Lood discovered that the "acne bacterium" secretes a protein called RoxP. This protein protects against what is known as oxidative stress, a condition in which reactive oxygen species damage cells. UV radiation from the sun is the common cause of oxidative stress.

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Oxidative stress is a contributing factor in a variety of skin diseases, including atopic dermatitis, psoriasis and skin cancer. Propionibacterium acnes is present in both healthy individuals and people with skin diseases. However, people have different amounts of the bacterium on their skin and the production of protective protein RoxP varies.

"This protein is important for the bacterium's very survival on our skin. The bacterium improves its living environment by secreting RoxP, but in doing so it also benefits us," explains Rolf Lood.

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The researchers will further investigate the effect of protein in both patients and laboratory animals. The human study will involve patients with basal cell carcinoma. The researchers hope to investigate whether there is a connection between the degree of illness and the amount of RoxP on the patient’s skin. In laboratory animals, the study will examine whether RoxP also functions as protection.

"If the study results are positive, they could lead to the inclusion of RoxP in sunscreens and its use in the treatment of psoriasis and atopic dermatitis," hopes Rolf Lood.

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Increased oxidative stress has been strongly linked to conditions like atherosclerosis and age-related macular degeneration (AMD)

The findings of the study have been published in the Nature journal Scientific Reports.

Source-Medindia