Scientists have made a groundbreaking discovery in the fight against HIV/AIDS with the successful resolution of the enigmatic immune-evading HIV protein complex.
Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
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What is APOBEC3G
“APOBEC3G (A3G) is a key component of the human innate immune system to defend against invading HIV viruses, getting a ride inside budding virions like in a Trojan horse so that it can modify and disable viral DNA after reverse transcription in infected cells,” Prof. Wolf, the senior author of the study and who leads the OIST Molecular Cryo-Electron Microscopy Unit explains. “But HIV-1 has evolved a counteraction mechanism in the form of its Vif protein, which inhibits this process by binding to and degrading A3G, leading to successful amplification of infectious viral particles.”
About AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV
‘The study has identified precise interactions between a protein and the RNA ligand. These interactions could potentially serve as targets for drug development in future antiviral treatments against HIV/AIDS. #AIDS #HIV’
A unique aspect of their study is the first demonstration that this complex formation is mediated by specific RNA sequences, even though single-stranded DNA is the substrate of degradation by A3G. Their protein construct was optimized for higher solubility and could replicate the degradation pathway by A3G ubiquitination (a process that involves the transfer of ubiquitin polyubiqitination to a target protein and is important in many physiological functions) in vitro.
Reference:
- Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G - (https://www.nature.com/articles/s41467-023-39796-5)
Quiz on HIV / AIDS
Statistics tell us that the world HIV+ population has risen drastically from 8 million in 1990 to a whopping 33 million in 2007! Even more alarming is the fact that young people (below the age of 25) account for half of these infections! This is adequate proof for the lack of awareness among the general public even in these modern times. So take our quiz and brush up on the essential facts of HIV/AIDS.
There are 10 questions on HIV / AIDS in this quiz that will explore the depth of your knowledge and provide answers to the following:
Statistics tell us that the world HIV+ population has risen drastically from 8 million in 1990 to a whopping 33 million in 2007! Even more alarming is the fact that young people (below the age of 25) account for half of these infections! This is adequate proof for the lack of awareness among the general public even in these modern times. So take our quiz and brush up on the essential facts of HIV/AIDS.
There are 10 questions on HIV / AIDS in this quiz that will explore the depth of your knowledge and provide answers to the following:
- Immune control of HIV ()
- Symptoms of HIV/AIDS ()
- Cure for AIDS ()
- Acute HIV syndrome ()
- World AIDS day ()
- Western blot ()
Latent HIV Found Seeking Refuge in the Brain
A recent study shows that HIV can go latent in the brain, and stopping therapy can restart the development of infection to AIDS.
A recent study shows that HIV can go latent in the brain, and stopping therapy can restart the development of infection to AIDS.
