Redefining Sepsis as Per Startling Discovery from Southern Sweden

Sepsis, as prevalent as cancer and as fatal as a heart attack, emerged as a widespread threat in a 2016 study conducted in southern Sweden (Skåne), challenging prior perceptions (1^✔ ✔Trusted Source
Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review

Go to source). The incidence turned out to be 750 adults per 100,000 individuals. In the latest study in the same region, the results showed that more than four percent of all hospitalizations involved the patient suffering from sepsis, and 20 percent of all sepsis patients died within three months.

“This makes sepsis as common as cancer with similar negative long-term consequences, and as deadly as an acute myocardial infarction.

Among sepsis survivors, three-quarters also experience long-term complications such as heart attacks, kidney problems, and cognitive difficulties”, says Adam Linder, sepsis researcher and associate professor at the Department of Infection Medicine at Lund University, as well as a senior physician at Skåne University Hospital.

The European Sepsis Alliance has assigned the researchers to assess how common sepsis is in the rest of Europe.

Bridging the Gap Between Commonality and Lethality

Given the differing healthcare systems across countries, it wasn't immediately clear how they should proceed to obtain accurate figures. Consequently, the researchers conducted a pilot study in southern Sweden to determine if their methods applied to other European hospitals.

“Doctors classify patients using diagnostic codes. Since sepsis is a secondary diagnosis resulting from an infection, the condition is significantly underdiagnosed, as the primary disease often dictates the diagnostic code. This makes it challenging to find a way to accurately determine the number of sepsis cases”, says Lisa Mellhammar, a sepsis researcher at Lund University and assistant senior physician at Skåne University Hospital.

In the study, which is now published in JAMA Network Open, it was revealed that 7,500 patients in Skåne were associated with sepsis in 2019. During the pandemic, the incidence increased to six percent.

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However, even without COVID-19, the researchers believe that sepsis should be viewed as an epidemic.

The aim is to use the publication to influence the EU to establish a common surveillance system for sepsis. The team is in contact with authorities and researchers from around thirty European countries and hopes that the research project can secure sufficient funding to start soon.

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There is no indication that the number of sepsis cases would be lower in other parts of Europe than in Sweden. In Swedish hospitals, only two percent of all sepsis patients are antibiotic-resistant, and the researchers speculate that the proportion of resistant cases is higher in many other European countries.

“Although sepsis care has improved in recent years, we need to enhance our diagnostic methods to identify patients earlier and develop alternative treatment methods beyond antibiotics to avoid resistance. Increasing awareness about sepsis among the public and decision-makers is crucial to ensure that resources are allocated appropriately", concludes Adam Linder.

Reference:

1. Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review - (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2808870)

Source-Eurekalert