Say Goodbye to Injections, Hello to Oral Relief With Robotic Pills for Osteoporosis

Groundbreaking development in osteoporosis treatment—a robotic pill that delivers medication orally.

A study presented at ENDO 2023 has unveiled a promising advancement in the treatment of osteoporosis.

Researchers have successfully developed a novel "robotic pill" capable of orally delivering a proven and effective medication for osteoporosis, which was previously only available through injections.

Osteoporosis-Causes-Symptoms-Diagnosis-Treatment-FAQs
Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduced and the bones are porous, thereby resulting in weakness of the skeletal system of the body.

‘Breaking the injection barrier, the oral robotic pill transforms the treatment landscape, improving convenience and potentially enhancing patient outcomes in managing this chronic condition. #Osteoporosis #RoboticPill’

The innovative technology, developed by Rani Therapeutics, offers hope to individuals suffering from chronic conditions that require painful injections, such as osteoporosis. By providing a painless and efficient alternative, this oral robotic pill could revolutionize the way osteoporosis medications are administered, improving patient convenience and treatment outcomes ().

“We believe this study provides the first clinical evidence of safe and successful delivery of the osteoporosis drug teriparatide through an oral robotic pill,” said Arvinder Dhalla, Ph.D., who leads Clinical Development at Rani Therapeutics, the San Jose, Calif.-based company that developed the technology and funded the study. “Data from this study are very encouraging and should give hope to those suffering from chronic conditions that require painful injections, like osteoporosis, that an oral alternative could be on the way.”

Robotic Pill: a Painless Alternative to Deliver Osteoporosis Drug

When a person swallows the robotic pill, it moves through the stomach intact. In the intestine, the pill releases a self-inflating balloon with a micro syringe, which injects a drug-filled microneedle and delivers the medication.

“The intestines do not have pain response to needles, so the injection is painless,” Dhalla said. The needle rapidly dissolves, and the medication is absorbed while the delivery mechanism deflates and is safely passed out of the body.

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“The robotic pill, which is essentially a swallowable auto-injector in the form of a pill, is designed to deliver the drug safely and efficiently as a painless intestinal injection,” she said.

The Phase I study of 39 healthy women evaluated the safety, tolerability, and movement through the body of the robotic pill known as RT-102, containing a dose of the drug teriparatide (PTH 1-34). Teriparatide is a synthetic form of the natural human parathyroid hormone.

It has been in clinical use for decades as an injectable medication (under the brand name Forteo®) for rebuilding the brittle bones of osteoporosis patients. It is taken as a daily injection for up to two years.

Study participants were divided into three groups. Two groups received either a lower or higher dose delivered with the robotic pill, and the third group received a standard injection of teriparatide.

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Osteoporosis is a bone disease in which bones become porous, thin, brittle, and prone to fracture. Osteoporosis can occur in both the genders, but is much more common in post-menopausal women. View interesting facts on osteoporosis.

Fluoroscopic imaging was used to track the robotic pill through and out of the body. Drug concentrations were measured in blood samples collected over six hours. The study found the bioavailability (the ability of the drug to be absorbed and used by the body) of the drug delivered by the robotic pill was comparable to or better than the drug given via the injection.

“This breakthrough technology of converting injections into oral pills is a significant step forward towards ending the burden of painful injections for millions of patients suffering from chronic diseases,” Dhalla said.

Reference:

Challenges and Opportunities in the Oral Delivery of Recombinant Biologics - (https://pubmed.ncbi.nlm.nih.gov/37242657/)

Source-Eurekalert