Researchers have found that mild Zika virus infection in fetuses can cause abnormal brain development in apparently healthy young animals this might be applicable to humans as well.

‘We are now able to understand better the disease in fetuses and how it affects health in offspring.’
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Spread by the bite of an infected Aedes species mosquito, Zika infection of pregnant mothers can lead to death and decreased brain size (microcephaly) in fetuses, leading to life-long developmental and cognitive impairment.Read More..





However, there is growing concern that sub-clinical infections (showing no symptoms) in pregnant mothers can result in brain disorders and delayed neurodevelopmental abnormalities in offspring after birth.
Using the pig as a model, new research at USask's Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) has provided direct evidence to support this concern.
"We have demonstrated in a relevant animal model that mild infection in fetuses results in abnormal brain development and impaired immunity in young pigs," said VIDO-InterVac Director Dr. Volker Gerdts, who also participated in the study. Some of the affected offspring also showed altered behavior during stress.
"For the first time, we have shown that mild fetal infection can lead to sex-specific brain disease in offspring: male piglets showed more molecular brain abnormalities than female piglets," said Dr. Uladzimir Karniychuk, senior author of the study, who with colleagues developed the novel animal model.
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Karniychuk said the next step is to develop an animal model for the study of how to treat and cure infections such as the Zika virus in utero. There are currently no in utero therapies for congenital viral infections. Earlier this year, Karniychuk was awarded $250,000 over two years by the federal New Frontiers in Research Fund to undertake this work aimed at reducing the long-term consequences of abnormalities in developing fetuses and the treatment required after birth.
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Source-Eurekalert