Researchers at University of Nottingham studying the caterpillar fungi, Cordyceps, have found that cordycepin, a drug found in the mushrooms, can be used in developing new cancer drugs.
![Caterpillar Fungi’s Anti-Inflammatory Properties can be Utilized in Developing Drugs for Number of Conditions Caterpillar Fungi’s Anti-Inflammatory Properties can be Utilized in Developing Drugs for Number of Conditions](https://images.medindia.net/health-images/1200_1000/druks1.jpg)
Several studies have suggested that cordycepin could be an effective drug for a variety of conditions, including cancer, stroke, kidney damage and inflammatory lung disease but until now it was unclear how cordycepin could bring about so many different beneficial effects at the cellular level.
Dr de Moor said: "We have shown that cordycepin reduces the expression of inflammatory genes in airway smooth muscle cells by acting on the final step in the synthesis of their messenger RNAs (mRNAs) which carry the chemical blueprint for the synthesis of proteins. This process is called polyadenylation. Commonly used anti-inflammatory drugs either work much earlier in the activation of inflammatory genes, such as prednisone, or work on one of the final products of the inflammatory reaction (e.g. ibuprofen).These findings indicate that cordycepin acts by a completely different mechanism than currently used anti-inflammatory drugs, making it a potential drug for patients in which these drugs don't work well.
"However, it is a surprise that cordycepin does not affect the synthesis of mRNAs from other genes, because nearly all mRNAs require polyadenylation."
Dr de Moor's research suggests that this is because inflammatory genes can be very rapidly induced and that cordycepin has its many and varied effects by altering the synthesis of other classes of rapidly induced genes as well. If this is true if could be said that cordycepin slows down the rapid cellular responses to tissue damage and may work by preventing the over-activation of these responses which are associated with conditions such as asthma, rheumatoid arthritis, renal failure, cancer and stroke damage.
However, it also indicates that cordycepin could have adverse effects on normal wound healing and on the natural defences against infectious diseases.
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