Antibiotics and The Gut Microbiota, Getting the Right Balance

Antibiotics have been potentially life-saving tools that are valuable and have significantly reduced human morbidity and mortality. Unfortunately, antibiotics may also have unintended consequences from their off-target effects that may increase the risk of many long-term conditions. Recent epidemiologic studies have detected a possible link between antibiotic use in childhood and weight gain1 - with disruption to the normal gut microbiota considered the most likely cause.

"Infancy is an important time in the development of the human microbiota and these studies provide evidence that early exposure to antibiotics may disrupt the early-life microbiota and lead to changes in growth and metabolic development," says Dr Laura Cox (New York University, USA). "In animal studies, we are carefully trying to understand how the intestinal microbiota influences body composition and metabolism and what impact antibiotics might have."

Her talk was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL, USA. On March 8-9, 2014, internationally leading experts discussed the latest advances in gut microbiota research and its impact on health.

Antibiotics came into widespread use after the Second World War, with substantial public health benefits. Use of antibiotics has increased markedly, with infants and children averaging one course of antibiotics every year. Longstanding concerns over the broadening and sometimes inappropriate use of antibiotics (e.g. self-medication, use in viral infections, empirical use of broad-spectrum agents in cancer patients with neutropenia) have focussed primarily on the development of bacterial resistance, but it seems clear that antibiotics can also affect the bacteria we need in our guts, as well as those we want to eradicate. This, it seems, could have serious long-term consequences to our health.

Microbiota beyond the gut The intestinal microbiota, composed of trillions of microbial cells, undertakes many vital immune, hormonal and metabolic functions. Disruption to normal colonization - through the over-use of antibiotic therapy - could, it has been suggested, be fueling the dramatic increase in conditions such as obesity, type 1 diabetes, inflammatory bowel disease, allergies and asthma, which have more than doubled in prevalence in many populations. Evidence is also mounting that microbiota resilience decreases with each subsequent course of antibiotics2 and that, once disrupted, the normal microbiota may never recover completely or it may be replaced by resistant organisms.3,4

"We are just beginning to understand the roles that the intestinal microbiota plays in normal growth and development," says Dr Cox, "and further studies in both humans and experimental animal models are needed to characterize the potential impact of antibiotics on the microbiota and host physiology."

Body composition and metabolism The spotlight has recently fallen on the role of the gut microbiota in normal growth and development, with scientists now concerned that altering the microbial balance in the gut with antibiotics may lead to weight gain. Low doses of antibiotics have been used for decades in the agricultural industry to promote weight gain in farm animals, and researchers have reported similar changes in body fat and tissue composition in laboratory animals given low-dose antibiotics.5 Studies are currently underway using sub-therapeutic antibiotic treatment as a tool to disrupt the microbial ecosystem and alter host body composition with the aim of identifying organisms within the microbiota that could either promote or protect against obesity.

"We are working hard to understand the link between antibiotic exposure, gut microbiota and body composition," explains Dr Cox. "Ultimately, our aim is to develop microbiota restoration strategies following antibiotic treatment to rebalance the gut microbiota and promote healthy growth and development."

The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting new areas of research today. To address the most recent advances in this rapidly developing field, scientists and health-care professionals from all over the world came together at the Gut Microbiota for Health World Summit in Miami, Florida, USA, on March 8-9, 2014. The meeting was hosted by the Gut Microbiota & Health Section of the European Society of Neurogastroenterology and Motility (ESNM) and the American Gastroenterological Association (AGA) Institute, with the support of Danone.

Source: Eurekalert