Brain Cancer Could be Detected Earlier With a Simple Urine Test
A new device to identify a key membrane protein in the urine that indicates whether the patient has a brain tumor has been discovered by researchers at Nagoya University in Japan. This research could have potential implications for detecting other types of cancer. The research was published in ACS Nano.
Their protein could be used to detect brain cancer, avoiding the need for invasive tests, and increasing the likelihood of tumors being detected early enough for surgery.
‘Small-sized cells in urine have specific types of RNA and membrane proteins, especially in brain cancer patients.’
Although early detection of many types of cancer has contributed to the recent increases in cancer survival rates, the survival rate for brain tumors has remained almost unchanged for over 20 years. Partly this is due to their late detection.
Physicians often discover brain tumors only after the onset of neurological symptoms, such as loss of movement or speech, by which time the tumor has reached a considerable size. Detecting the tumor when it is still small, and starting treatment as soon as possible should help to save lives.
Scientists Develop New Device to Detect Brain Tumors using Urine
One possible sign that a person has a brain tumor is the presence of tumor-related extracellular vesicles (EVs) in their urine. Because those found in brain cancer patients have specific types of RNA and membrane proteins, they could be used to detect the presence of cancer and its progression.Although they are excreted far from the brain, many EVs from cancer cells exist stably and are excreted in the urine without breaking down.
Urine tests are an effective, simple, and non-invasive method because the urine contains many informative biomolecules that can be traced back to identify the disease.
Researchers have developed a new analysis platform for brain tumor EVs using nanowires at the bottom of a well plate. Using this device, they identified two specific types of EV membrane proteins, known as CD31/CD63, from urine samples of brain tumor patients. Looking for these tell-tale proteins could enable doctors to identify tumor patients before they develop symptoms.
Currently, EV isolation and detection methods require more than two instruments and an assay to isolate and then detect EVs. The all-in-one nanowire assay can isolate and detect EVs using one simple procedure.
In the future, users can run samples through our assay and change the detection part, by selectively modifying it to detect specific membrane proteins or miRNAs inside EVs to detect other types of cancer.
Using this platform, we expect to advance the analysis of the expression levels of specific membrane proteins in patients' urinary EVs, which will enable the early detection of different types of cancer.
Source: Eurekalert