Gene Mechanism That Reduces Risk of Gene Variant Carriers Developing Heart Disease Discovered

A new gene mechanism that can protect carriers of a gene variant against cardiovascular diseases by regulating triglyceride levels have been identified by American researchers.

The findings by scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University contribute to research efforts to develop gene-specific diets that could potentially improve general health and complement chronic disease prevention and treatment.

The authors analyzed data from more than 27,000 men and women enrolled in ten epidemiological studies conducted in the United States and Europe that comprise the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

Focusing on the Single Nucleotide Polymorphism (SNP) rs13702, they observed that a type of small RNA known as microRNA (miR), impacts production of lipoprotein lipase (LPL), an enzyme that mediates the metabolism of circulating triglycerides.

"We saw no miR activity in carriers of the gene variant," senior author Jose M. Ordovas from Tufts University said.

"In the majority of the subjects the miR appeared to attach to the messenger RNA (mRNA), slowing down the manufacturing of LPL. Without that interference, people with the variant would presumably have more LPL available to breakdown excess triglycerides and prevent them from being deposited in the arteries, which could eventually lead to atherosclerosis and other cardiovascular diseases," Ordovas said.

The authors also noted that lower triglyceride levels and higher concentrations of high-density lipoprotein (HDL) cholesterol, the so-called "healthy" cholesterol in association with the gene variant.

Furthermore, carriers tended to have even lower triglyceride blood levels if they had higher PUFA intake.

"Based on the data, carriers of the gene variant may be able to further reduce their risk for cardiovascular disease by increasing their PUFA intake," Kris Richardson from Tufts University said.

"To build on our observational data, future studies might investigate the effect of treating human cells in culture with PUFA to determine if it will mediate LPL levels through the identified miR," Richardson said.

PUFA, found in foods like salmon and vegetable oils, is considered a healthier fat.

The study has been published online in the American Journal of Human Genetics.

Source: ANI