Preimplantation genetic testing (PGT) was found to help prospective parents to prevent passing on disease-causing mutations to their children, said researchers.
In Vitro Fertilization (IVF) - Introduction To Infertility and Reproduction
Encyclopedia section of medindia gives a brief introduction to infertility and reproduction
Encyclopedia section of medindia gives a brief introduction to infertility and reproduction
‘The number of couples counselled on Preimplantation genetic testing (PGT) for monogenic kidney disease steadily increased over time. Ninety-eight couples were counselled regarding PGT, of whom 53% opted to proceed with testing, 38% chose not to proceed, and 9% had not yet decided whether to proceed as of June 2019.’
"PGT is a relatively recent addition to the options couples at risk for having a child with monogenic kidney disease have," said Dr. van Eerde. "There was no literature on the range of indications PGT has been performed for, success rates, and reasons for opting out after having been informed." The most frequent indications for testing were autosomal dominant polycystic kidney disease (38%), Alport syndrome (26%), and autosomal recessive polycystic kidney disease (9%). Also, 45% of procedures were performed for adult onset kidney disease, with an increase to over 50% in recent years. Of couples with at least one PGT cycle with egg retrieval, 65% experienced one or more live births of a child without kidney disease.
The authors noted that as the number of kidney diseases for which a monogenic cause can be identified continues to grow, it becomes increasingly important to counsel patients on their reproductive options to enable them to make informed choices.
Genes Help Predict Tolvaptan Effectiveness in Polycystic Kidney Disease
Genetics was found to help predict the effectiveness of tolvaptan in autosomal dominant polycystic kidney disease.
Genetics was found to help predict the effectiveness of tolvaptan in autosomal dominant polycystic kidney disease.
An accompanying editorial noted that in the absence of insurance coverage, costly genetic services are primarily available to those who can pay out of pocket, and limits in the coverage of assisted reproductive technology disproportionately burden racially marginalized groups. The authors stressed that there is a need to address moral questions about the acceptable use of PGT, and to ensure access based on need rather than ability to pay. "Payers, including government programs, may be more likely to include coverage of preimplantation genetic testing if professional organizations offer stringent guidelines for its use that have the dual goal of preventing the birth of children with serious disease while supporting equitable access," they wrote.
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Invitro Fertilisation
During IVF fertilization takes place invitro, in an incubated petri dish. The resulting embryo is transferred back to the uterus on Day 3 at the 6-8 cell stage. Sometimes the embryo transfer in done at the blastocyst stage on Day 5. The embryo is drawn into a specialized catheter along with a small amount of culture medium and is transferred to the uterus.
During IVF fertilization takes place invitro, in an incubated petri dish. The resulting embryo is transferred back to the uterus on Day 3 at the 6-8 cell stage. Sometimes the embryo transfer in done at the blastocyst stage on Day 5. The embryo is drawn into a specialized catheter along with a small amount of culture medium and is transferred to the uterus.
Healthy Foods for People with Kidney Disease
For people with kidney disease, the choice of foods becomes limited. Here’s a list of healthy foods that promote kidney health.
For people with kidney disease, the choice of foods becomes limited. Here’s a list of healthy foods that promote kidney health.
