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CRISPR-Cas9 Gene Editing Creates Invisible Stem Cells

by Namitha Kumar on February 25, 2019 at 5:54 PM
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Autologous induced pluripotent stem cells (iPSCs) are a great source of regeneration for organ and tissue repair. iPSCs are made from fully mature fat or skin cells and can be reprogrammed to develop into any cells comprising tissues or organs. However, iPSCs have proved to be difficult at the clinical level as patients are unreceptive to reprogramming and the process is time-consuming and expensive.


To circumvent these problems, scientists at the University of California, San Francisco have created �universal' induced pluripotent stem cells (iPSCs) which can be safely used for transplants without being attacked by the body's immune system. Scientists used CRISPR-Cas9 to edit three genes to avoid rejection.

‘Scientists have created �universal� induced pluripotent stem cells (iPSCs), which can be safely used for transplants without being attacked by the body�s immune system.’

This neat bit of biogenetic engineering in lab studies has made pluripotent stem cells which are functionally �invisible' to the immune system thereby eliminating the risk of immune system attacks and rejection.

(https:www.ucsf.edu/news/2019/02/413311/crispr-gene-editing-makes-stem-cells-invisible-immune-system)

Source: Medindia

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