Relaxation Response Alters Gene Expression to Help Reduce Blood Pressure

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Highlights:

• Relaxation response alters gene expression in a specific set of genes which help in lowering blood pressure.
• The relaxation response could successfully help reduce blood pressure in hypertensive patients who are not taking medication.
• The changes in gene expression associated with drop in blood pressure are consistent with the physical and inflammatory markers that one would anticipate in patients successfully treated for hypertension.

It has been identified that relaxation technique, can alter gene expression and thereby help in lowering blood pressure. The study conducted by research teams at Beth Israel Deaconess Medical Center (BIDMC), Massachusetts General Hospital (MGH), and the Benson-Henry Institute for Mind Body Medicine at MGH has identified genes associated with the body's response to relaxation techniques which may aid to lower blood pressure. The findings are published in the Journal of Alternative and Complementary Medicine.

The relaxation response

The relaxation response is the physiological and psychological opposite of the well-known fight-or-flight stress response. The response can be achieved through relaxation techniques like yoga or meditation and has been shown to reduce blood pressure in people with hypertension.

The relaxation response is characterized by a set of measurable changes to the body, including decreased respiration rate and heart rate. However, the molecular mechanism of how this works has remained unclear.

Relaxation response and hypertension

Hypertension or High Blood Pressure affects 1 billion people worldwide and is a major risk factor for heart attack and stroke. Traditionally, high blood pressure is treated with medications, but many patients experience treatment-limiting side effects. Alternative strategies to lower blood pressure are crucial in such patients.

‘Relaxation response reduces blood pressure by altering gene expression associated with immune regulation, metabolism, and circadian rhythm. ’

The new study has found that the relaxation response can successfully help reduce blood pressure in hypertensive patients who are not taking medication.

Study overview

Fifty eight people with Stage 1 essential hypertension were enrolled in the study. Stage 1 essential hypertension is defined as having a systolic blood pressure between 140-159mm Hg and diastolic between 90-104mm Hg. The participants were either not taking medications or had tapered off them for five weeks prior to the outset of the study. All participants were also asked to fill out standardized questionnaires about stress, depression and anxiety.

Over the next eight weeks, participants attended 8 weekly training sessions of mind-body interventions designed to elicit the relaxation response. The training included diaphragmatic breathing, mantra repetition and Mindfulness Meditation.

After the 8 weeks of training, patients were asked to fill out the same stress, depression and anxiety questionnaires. Blood was also drawn from participants for gene expression testing along with blood pressure measurement.

Study findings

• Overall, 13 of the 24 participants who completed the eight-week intervention experienced a clinically relevant drop in blood pressure (below 140/90 mm Hg).
• Patients whose blood pressure dropped below 140/90 mm Hg were called responders while those who still fell within the definition of Stage I hypertension were called non-responders.
• Specific gene expression changes were observed in the responders over the course of the eight-week relaxation response intervention that were not observed in the non-responders.
• Among responders, the expression of 1,771 genes differed between the baseline blood tests and those that were taken after the 8 weeks of relaxation response practice.
• Reduction in blood pressure was correlated with genes linked to immune regulatory pathways, metabolism and glucose metabolism, cardiovascular system development and circadian rhythm.

"Our results suggest that the relaxation response reduced blood pressure - at least in part -- by altering expression of genes in a select set of biological pathways," co-first author John Denninger, MD, PhD, Director of Research at the Benson-Henry Institute, noted. "Importantly, the changes in gene expression associated with this drop in blood pressure are consistent with the physical changes in blood pressure and inflammatory markers that one would anticipate and hope to observe in patients successfully treated for hypertension."

References:

1. Relaxation Response May Reduce Blood Pressure by Altering Expression of a Set of Genes - (https:www.bidmc.org/about-bidmc/news/relaxation-response-may-reduce-blood-pressure-by-altering-expression-of-a-set-of-genes-1)
2. Manoj K B, John W D, Jeff C H, Marie G J, Halsey N, Emma C F , Roberta G, Beverly B K, Barbara A M, Gregory L F, Jeffery A D, Herbert B, Randall M Z, Towia A L, "Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation Response Training", Journal of Alternative and Complementary Medicine (2018) doi.org/10.1089/acm.2017.0053

Source: Medindia

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