Breakthrough Stroke Drug Shows Promising Results
Highlights:
- Researchers at the University of Colorado Anschutz Medical Campus have developed a promising stroke drug
- The drug temporarily inhibits a key brain protein, providing neuroprotective effects
- It prevents brain cell damage and shows potential for treating conditions like Alzheimer's disease
A groundbreaking study conducted by scientists at the University of Colorado Anschutz Medical Campus has unveiled a new stroke drug that could revolutionize the treatment of cerebral and global ischemia. By temporarily inhibiting a key protein in the brain without causing lasting harm, this drug offers significant neuroprotective effects. The findings, published in the Journal of Biological Chemistry, demonstrate the potential of this drug in transforming stroke therapy (1✔).
Targeting the Critical Protein That Regulates Learning and Memory
The researchers aimed to target a vital protein known as Ca2+/calmodulin-dependent protein kinase II (CaMKII), responsible for regulating learning and memory. Previous concerns regarding long-term interference with this protein raised doubts about potential negative side effects. However, using animal models, the team administered a neuroprotective peptide called tatCN19o to target the protein.New Drug Exhibits Neuroprotective Effects and Causes Temporary Learning Impairment
Excitingly, the study revealed that tatCN19o did not impact pre-formed memories and only caused temporary learning impairment for less than an hour. The drug also displayed remarkable efficacy in preventing brain cell damage, even at low doses and when administered within 30 to 60 minutes after ischemic events.Promising Applications in Stroke Treatment and Alzheimer's Disease
The temporary learning impairment caused by the drug in cases of global cerebral ischemia or stroke was deemed highly acceptable, especially considering that the treatment involves a single acute bolus of the drug. This short duration of learning impairment opens up possibilities for chronic treatments of various conditions, such as Alzheimer's disease.
The study's co-authors highlight the significance of the findings, indicating that briefly inhibiting the critical protein does not lead to long-term amnesia. With further safety studies expected to be conducted soon, human trials of this groundbreaking drug could commence within the next three years. Neurexis Therapeutics, the licensee of this technology, is currently advancing the drug through late preclinical development.
‘Exciting breakthrough in stroke treatment! A new drug offers neuroprotection without long-term harm. Learn how it could transform therapy and benefit patients. #StrokeTreatment #Neuroprotection’
The discovery of this novel stroke drug represents a breakthrough in the treatment of cerebral and global ischemia. By temporarily inhibiting the key protein CaMKII, the drug demonstrates significant neuroprotective effects and minimal negative side effects. The potential applications extend beyond stroke treatment, holding promise for chronic conditions like Alzheimer's disease. As further research and trials progress, the medical community eagerly anticipates the transformative impact this drug could have on stroke therapy and related neurological disorders.
Reference:
- Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs - (https:www.jbc.org/article/S0021-9258(23)00335-6/fulltext#%20)
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Dr. Trupti Shirole. (2023, May 24). Breakthrough Stroke Drug Shows Promising Results. Medindia. Retrieved on Dec 26, 2024 from https://www.medindia.net/news/healthwatch/breakthrough-stroke-drug-shows-promising-results-211924-1.htm.
MLA
Dr. Trupti Shirole. "Breakthrough Stroke Drug Shows Promising Results". Medindia. Dec 26, 2024. <https://www.medindia.net/news/healthwatch/breakthrough-stroke-drug-shows-promising-results-211924-1.htm>.
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Dr. Trupti Shirole. "Breakthrough Stroke Drug Shows Promising Results". Medindia. https://www.medindia.net/news/healthwatch/breakthrough-stroke-drug-shows-promising-results-211924-1.htm. (accessed Dec 26, 2024).
Harvard
Dr. Trupti Shirole. 2023. Breakthrough Stroke Drug Shows Promising Results. Medindia, viewed Dec 26, 2024, https://www.medindia.net/news/healthwatch/breakthrough-stroke-drug-shows-promising-results-211924-1.htm.