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How Depression and Sleep Disturbances Affect Menstrual Pain

Study highlights depression's role in worsening menstrual pain and suggests sleep disturbances as a key factor.

by Dr. Preethi Balasubramanian on November 28, 2024 at 12:33 PM
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Highlights:

Dysmenorrhea can be influenced by depression through genetic factors and factors such as sleep disturbances as a result of a recent study that has been published in Briefings in Bioinformatics (1).


Genetic Links Between Depression and Menstrual Pain

There are some genetic factors which connect depression and menstrual pain as follows:

Did You Know?
Depression may increase the risk of menstrual pain, highlighting the need for integrated care! #medindia #healthresearch’

A team of researchers from Xi'an Jiaotong-Liverpool University (XJTLU), China and University of Liverpool, UK genotypically compared the data collected from over 600, 000 individuals drawn from Europeans and East Asians. They then proposed potential genes associating depression with menstrual pain through a method known as Mendelian randomisation.

Key insights include:

Role of Sleep Disturbances

The study further indicates that poor sleep which is linked to depression may worsen the level of pain during menstruation. Broken sleep raises hormonal irregularities and enhances pain sensitivity, thus during dysmenorrhea, this will progress the intensity of the symptoms.

This might also intensify depression with poor quality of sleep getting intensified, meaning intense menstrual pain leads to poor sleep and these can worsen both. Handling disturbed sleep with strategies including cognitive-behavioral therapy for insomnia, or stress reduction or with a pharmacological intervention, is an important part of the concurrent management of both.

Implications for Treatment

Lead researcher Shuhe Liu emphasized the importance of a holistic approach to treatment, advocating for:

The present study re-emphasizes the interrelation between neurological and physical well-being, implying that managing depression and related sleep further intervenes with menstrual cramps. The knowledge of these connections might allow for developing tailor-made therapeutic interventions helping millions of people suffering from both diseases.

Reference:

  1. Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study - (https:academic.oup.com/bib/article/26/1/bbae589/7908576)

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