HIV-1 Infections may be Stronger from Penile-Vaginal Intercourse

HIV-1 is more virulent and powerful when transmitted through penile-vaginal intercourse (due to transmission bottlenecks) than anal intercourse, revealed study published in PLOS Pathogens.

Transmission bottlenecks introduce selection pressures, or evolution opportunities that result in a fitter virus. A pathogen that causes more severe disease is said to be more virulent, and fitter strains tend to be more virulent. Reduction in helper T cells early in infection is associated with more virulent strains.

‘Transmission bottlenecks are expected to drive HIV-1 evolution and influence the design of prevention strategies.’

However, how these changes manifest in different risk groups has not been previously described. To better understand differences in transmission-related virus fitness in men-who-have-sex-with-men (MSM) and individuals who engaged in penile-vaginal intercourse, researchers analyzed T cell counts by collating data previously collected in large studies of MSM and non-MSM individuals infected with HIV. The researchers were able to compile data from 340,000 infected individuals of a range of ethnicities from over 25 countries.

The authors found that infections transmitted via penile-vaginal intercourse correlated with lower T cell counts than in the MSM risk group, suggesting greater selective pressure at transmission, and, in turn, resulting in more virulent strains than in transmission by MSM. However, the study was limited by its reliance on population level datasets that could not account for specific behaviors that increased or decreased risk of infection or stratify non-sexually transmitted infections in either risk group. Further studies are needed to analyze individual level transmission and infection data.

According to the authors, "The bottlenecks are affected by the mode of transmission. Because different risk groups tend to use different predominant modes of transmission, it is possible that the strains of HIV-1, directly affected by the bottlenecks, may have evolved differently in the different groups. These findings have implications for our understanding of HIV-1 pathogenesis, evolution, and epidemiology."

"Different modes of transmission of HIV from one individual to another can exert different bottlenecks on the virus," Dixit adds. "Analysis of early CD4 count measurements from over 340,000 patients reveals more virulent transmitted HIV strains in heterosexual individuals than men-who-have-sex-with-men, potentially affecting the HIV epidemic differently in these groups."

Source: Eurekalert