Individual Human Gene may Cause Various Cancers

Human-specific connection between advanced carcinomas and a gene called SIGLEC12 has been revealed in the study published in FASEB BioAdvances.

Human cancers start in epithelial cells of the skin or the tissue that covers the surface of internal organs and glands, and they include prostate, breast, lung, and colorectal cancers.

‘Expression of mutant form of Siglec-XII on epithelial cells could lead to the development of various aggressive cancers.’

Additional studies related to this gene, which has several uniquely human features, and the protein it encodes (called Siglec-XII) could potentially lead to broad-based advances in cancer prognostics, diagnostics, and therapeutics.

"Siglecs are typically expressed in immune cells, and it was surprising to find Siglec-XII on epithelial surfaces. While a mutant form of Siglec-XII is expressed only in about 30% of normal humans, it was found to be present in a high proportion of advanced carcinomas.

This could help explain why humans are more prone to aggressive carcinomas, which are rare in chimpanzees," said co-author Nissi Varki, MD, Professor of Pathology at the University of California San Diego School of Medicine.



Source: Eurekalert