Lactobacillus rhamnosus could dose-dependently reestablish a balanced gut microbiome and counter the liver-damaging effects of alcohol consumption to reverse the results of chronic alcohol-induced liver injury.
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Lactobacillus Balances Gut Health, Improves Chronic-alcohol-induced Liver Injury"
‘Lactobacillus rhamnosus granule supplementation can improve the gut microbiota, decrease the number of gram-negative bacteria, and improve alcoholic liver injury.’
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In this study, mice consumed alcohol for eight weeks and were fed Lactobacillus rhamnosus granules (LGG) the last two weeks, in varying doses (low, medium, and high) together with a high-fat diet. The researchers showed that LGG administration dose-dependently improved alcohol-induced liver injury by reducing fat accumulation and the inflammatory response in the liver. LGG consumption also ameliorated liver damage. The probiotic effect of the LGG restored a healthy balance in the gut microbiome, which was damaged by alcohol consumption. LGG reduced the number of gram-negative bacteria and increased gram-positive bacteria, including in the ileum and cecum.
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"This demonstration of the impact of a probiotic intervention correcting alcohol-induced dysbiosis and reducing liver inflammation and fat accumulation has exciting potential in the prevention and treatment of alcohol-induced liver disease as well as non-alcoholic fatty liver disease," states Journal of Medicinal Food Editor-in-Chief Michael Zemel, Ph.D., Professor Emeritus, The University of Tennessee and Chief Scientific Officer, NuSirt Biopharma.
Source-Eurekalert