Cause of Inflammation in obesity and type 2 diabetes mellitus (T2DM) helps to develop treatments to prevent complications from the disease which is the third leading cause of death in the United States.
![Mitochondrial Changes Cause Inflammation in Type 2 Diabetes Mitochondrial Changes Cause Inflammation in Type 2 Diabetes](https://images.medindia.net/health-images/1200_1000/sglt2-inhibitor-drug-for-type-2-diabetes.jpg)
‘Mitochondrial defects and accumulated fat derivatives were responsible for long-term inflammation in type 2 diabetes, which in turn cause various complications. New therapeutic approaches can be designed targeting mitochondrial changes.’
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The research was recently published in Cell Metabolism by a team led by Barbara Nikolajczyk (UK Barnstable Brown Diabetes Center, Department of Pharmacology and Nutritional Sciences) and Douglas Lauffenberger (MIT Department of Biological Engineering). Read More..
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Nikolajczyk and Lauffenberger didn't set out to disprove the glucose-inflammation causation theory. Based on the importance of glycolysis--a 10-reaction sequence that produces energy--in other types of inflammation, the team hypothesized that immune cells from patients with type 2 diabetes would produce energy by burning glucose. "We were wrong," Nikolajczyk said.
"We exclusively used immune cells from human subjects for all of the work, " Nikolajczyk explained, noting that humans, but not animal models of type 2 diabetes, have the specific pro-inflammatory T cell profile her team had identified in earlier research.
The team was surprised to find that glycolysis wasn't driving chronic inflammation. Instead, a combination of defects in mitochondria and elevated fat derivatives were responsible.
Nikolajczyk said she sees applications for this research in both basic and clinical sciences. She hopes to precisely define pro-inflammatory lipid types and explore associations between circulating and/or tissue-associated lipids and insulin resistance, one key feature of Type 2 diabetes. She is also interested in contributing to the development of new analytical approaches, spearheaded by Dr. Lauffenburger's team, that leverage ongoing lipid-related findings into a new understanding of pathology in type 2 diabetes.
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Source-Eurekalert