A potential way to prevent lack of oxygen or blood flow from causing long-lasting brain damage in newborn children has been discovered.
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‘A potential way to prevent lack of oxygen or blood flow from causing long-lasting brain damage in newborn children has been discovered.’
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Study Details
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- Histamine H2 receptor protein inhibits mature oligodendrocytes' formation capable of restoring the brain's white matter after injury.
- Mice lacking the histamine H2 receptor recovered better from neonatal hypoxia-ischemia.
- The mice regenerated more of their white matter and showed improved motor skills and cognitive function.
- Treating mice with cimetidine improved the animals' recovery from hypoxia-ischemia.
Hypoxic-ischemic encephalopathy (HIE)
- HIE is a condition that affects over 1 in 1,000 live births and can cause life-long neurological disabilities.
- HIE develops during pregnancy or from complications during labor and delivery.
- Premature infants at high risk of the disorder.
- It causes severe and long-lasting neurological disabilities, namely cerebral palsy, epilepsy, and cognitive impairment.
Source-Medindia