New Findings Enable More Heart Donations: Study

Many hearts are reported unfit for donation due to stress-induced heart failure. But a new study finds that this condition has no significance on the outcome of a transplant further opening path for up to 30 percent more heart transplants. The findings of the study are published in the journal Journal of Thoracic and Cardiovascular Surgery.

"Systematic utilization of these hearts would mean a breakthrough for heart transplantation, as more patients could be accepted for transplantation," says Jonatan Oras, senior lecturer at Sahlgrenska Academy, University of Gothenburg, and specialist physician in anesthesia and intensive care at the University Hospital.

‘Left ventricular dysfunction is common among potential heart donors. The use of these hearts might significantly boost transplantation rates. ’

The study is based on the particulars of 641 potential heart donors in Sweden in the years 2006-2016. Either these people, who had been declared brain-dead, had said yes to donation during their lives or their survivors had given the go-ahead.

As many as 24% of potential donors had acute stress-induced cardiomyopathy, or broken heart syndrome, in which cardiac function is impaired in one part of the heart, while the other parts beat normally. This condition is caused by the massive surge in stress hormones observed in the course of brain death.

The functional impairment appears to be transient: Within a few hours or days, the heart recovers. Nevertheless, there are recommendations that these hearts should not be transplanted.

The selection process, therefore, varies from one location to another. To date, the transplantation center in Gothenburg has had the favorable clinical experience of transplanting hearts with stress-induced heart failure, and there were 42 such cases in the current study.

The results show that when the donors' hearts had been subject to stress-induced heart failure, the outcomes for recipients were no different. Neither was mortality affected; rather, it conformed to the expected 20% rate in both groups after ten years.

"The impairment in cardiac function seems to be temporary and is not caused by coronary artery disease or other heart diseases. This fact fits well with stress-induced heart failure. When we repeatedly examine these hearts, we see that their function recovers quickly," Oras says.

More studies are to follow the current one to verify the results. Ending disqualification of donors with stress-induced heart failure is seen as especially urgent since the condition arises more often in young people, whose hearts are otherwise well suited for donation.

"We estimate that the supply of donor's hearts could be increased by 20-30% if these hearts are used," Oras concludes.

Source: Eurekalert