When injected, the anti-inflammatory molecule acts as a non-active drug. However, a localized site with excessive inflammation will activate it.
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The uniqueness of this novel anti-inflammatory molecule, reported in the current issue of Journal of Immunology, can be found in a singular property. When injected, it acts as a non-active drug. However, a localized site with excessive inflammation will activate it, the study said.
Most other anti-inflammatory agents effectively inhibit inflammatory processes, though in a non-specific manner and in areas that include sites of necessary normal inflammatory homeostasis. The researchers demonstrated their findings in a mouse model of local inflammation.
"The beauty of this invention lies in the use of a known natural biological code. We mimicked a natural process that occurs during inflammation," Rider said. "Upon resolution of inflammation, the activation of the protein is also reduced and side effects are avoided," he added.
Source-IANS