New Treatments for Inflammation and Infection Should Target Innate Lymphoid Cells That Induce T-Cell Responses

Researchers at University of Basel have found that innate lymphoid cells that are activated during inflammation induce specific T and B cell responses and these cells can prove to be an important target in developing new treatments for infection and chronic inflammation, a new study published in the journal PNAS reveals.

Innate lymphoid cells (ILCs) are immune cells that regulate early immune responses against viruses, bacteria and parasites through the release of soluble factors. These cells can be classified into three subsets that each have various functions. Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.

ILC3s internalize antigen and induce T cell responses

The research group lead by Prof. Daniela Finke found that ILC3s take up antigens and present these via so-called MHC molecules on their surface. Specific T cells then recognize these antigen-loaded MHC molecules and induce immune responses. The importance of this interaction between ILC3s and T cells for the immune defense was shown in mice that were lacking the MHC molecules on their ILC3s. These animals had severely reduced T and B cell immune responses.

Inflammatory signals activate ILC3s

So far, scientists assumed that ILC3s decreased T cell responses because they were lacking certain additional receptors required for efficient T cell stimulation. The research group of Prof. Finke was able to show for the first time that these important costimulatory receptors are produced by ILC3s when they are activated through inflammatory signals such as the soluble factor IL-1β. Moreover, ILC3s then produce factors that promote T cell responses.

The results of the Basel research team open up new ways for improving immune responses after vaccination and for preventing harmful immune responses for example during chronic inflammation.



Source: Eurekalert