PTSD Symptoms' Severity Associated With Reduced Activity in Hippocampus
Individuals with reduced activity in the hippocampus experience worse post traumatic stress disorder (PTSD) symptoms, revealed research.
The hippocampus does more than encode new memories - it also takes stock of spatial and emotional contexts and processes threat. PTSD impacts all of these functions, generating symptoms like the overgeneralization of fear and recurrent traumatic memories. Yet the exact interplay between the hippocampal activity and PTSD was unclear.
‘People more sensitive to threats show decreased brain activity and worse post traumatic stress disorder symptoms. ’
Tanriverdi et al. measured PTSD symptoms and hippocampal activity in people who had visited the emergency room after a traumatic event like a car crash. Participants answered a questionnaire about PTSD symptoms, then they viewed frightened and neutral faces while the researchers measured their brain activity with fMRI.
Severity of Post Traumatic Stress Disorder Symptoms
People with more severe PTSD symptoms had decreased activity in the hippocampus in response to the frightened faces. This relationship strengthened in people who startled more easily in a defensive learning task. For these participants, their hippocampus may not be discriminating between safe and unsafe contexts.These results indicate certain individuals may be more susceptible to PTSD because of impaired activity in their hippocampus.
Source: Eurekalert