Ray of Hope for Prostate Cancer Treatment Discovered
Five types of bacteria that are linked to aggressive prostate cancer have been identified in urine and tissue samples from men with the condition, according to a new study published in the journal European Urology Oncology.
Project lead Prof. Colin Cooper from the University of East Anglia's (UEA) Norwich Medical School, said: "We already know of some strong associations between infections and cancer. We wanted to find out whether bacteria could be linked to the way prostate cancer grows and spreads."
‘Men who had multiple bacteria species in their urine were 2.6 times more likely to develop an advanced form of prostate cancer than men who did not.’
Prostate cancer is very commonly known as the deadliest disease; it is almost always too late before the cancer is detected. And little is known about what causes some prostate cancers to become more aggressive than others.
To clear this puzzle, researchers were involved in the genetic analysis of urine and prostate tissue of around 600 men, both with and without prostate cancer.
They found five species of bacteria that overlapped with the aggressive cancer cells; three of these were identified for the first time. Based on the examination, the newly identified bacteria could potentially be an indicator of the disease's severity.
The set of bacteria found includes Anaerococcus, Peptoniphilus, Porphyromonas, Fenollaria, and Fusobacterium. All the bacteria like to grow without oxygen present.
When any of these specific anaerobic bacteria were detected in the patient's samples, it was linked to the presence of higher grades of prostate cancer and more rapid progression to aggressive disease.
They also identified potential biological mechanisms of how these bacteria may be linked to cancer. Yet there is no clarity on whether bacteria are causing cancer, or whether a poor immune response permits the growth of the bacteria.
Future work based on these findings and future work could lead to new treatment options that could slow or prevent aggressive prostate cancer from developing.
Source: Medindia