Vitamin A, which teens commonly use to deal with acne, may actually hold benefits that are more than just skin deep
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To make this discovery, scientists used cells isolated from mice and humans to conduct a head-to-head comparison of the role of all-trans retinoid acid (ATRA) on CD4+ and CD8+ Treg cell development. While ATRA significantly promoted CD4+Foxp3+Treg development and function in mice and humans, it did not boost the differentiation and function of CD8+Foxp3+Treg. On the contrary, ATRA interfered with the differentiation and function of human CD8+Foxp3+Treg. This suggests that ATRA-treated CD4+Treg is superior to ATRA-treated CD8+Treg for the treatment of autoimmune disease and organ transplantation. This lays the groundwork for the potential development of specific Treg subsets to combat specific autoimmune diseases and complications.
"The great thing about this discovery is that we already have a strong foundation of clinical use of this form of Vitamin A and know that it is well-tolerated by people," said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These findings are a great example of the ability to exploit currently used drugs and our growing molecular and cellular understanding of the immune system. Such approaches represent exactly the kind of merging of basic science and clinical medicine that defines translational research."
Source-Eurekalert