Why Do Women With Polycystic Ovary Syndrome Face Increased Death Risk?
Polycystic ovary syndrome (PCOS) individuals are prone to 47% higher mortality risk at a younger age, revealed research being presented at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill ().
What is PCOS?
PCOS is a common cause of infertility in women, and it occurs in 7% to 10% of women of reproductive age. Women with PCOS may have higher than normal levels of testosterone and other reproductive hormones called androgens, irregular periods, and/or cysts on the ovaries. The condition raises the risk of developing diabetes and cardiovascular conditions.
"The results highlight the need for improving the care of diabetes, lung infections and cardiovascular diseases to prevent the excess mortality of women with PCOS," said co-author Terhi Piltonen, M.D., Ph.D., of University of Oulu and Oulu University Hospital in Oulu, Finland.
Polycystic Ovary Syndrome: A Growing Risk of Death
Piltonen and colleagues conducted a register-based case-controlled study to challenge the limited data within the literature on the risk for mortality among people with PCOS. They identified women with PCOS in the Finnish Care Register for Health Care using ICD codes.‘Among women with polycystic ovary syndrome, diabetes, circulatory system disease and bronchitis boosted death risk. ’
The controls in the study were matched based on their year of birth and where they lived. Piltonen and colleagues included the records of 9,839 women with PCOS and 70,705 controls for the study.
Of the studied population, 1,003 controls and 177 women with PCOS died during the follow-up period, spanning the years 1969-2019. The data suggest women with PCOS died significantly younger than the controls. In an additional analysis, the women with PCOS had an increased risk for death as well as a greater risk for death due to tumors as well as endocrine, nutrition, metabolic diseases and cardiovascular disease. Similarly, overall mortality was also increased among women with PCOS due to disease of the cardiovascular system and tumors.
"The mortality due to diseases of the cardiovascular system was increased by 67 percent and mortality due to tumors by 38 percent when compared to the control group. Women with PCOS also had triple the risk of death due to diabetes and lung infection," Piltonen said.
"PCOS is a severe lifelong syndrome that increases mortality," Piltonen said. "More resources should be targeted on the prevention of PCOS-related diseases."
Reference:
- ENDO 2023 | Endocrine Society - (https:www.endocrine.org/meetings-and-events/endo2023)