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Botulism

Medically Reviewed by Dr. Lakshmi Venkataraman, MD on Sep 18, 2020


What is Botulism?

Botulism is a rare but serious condition which develops due to toxins produced by the bacterium Clostridium botulinum. Although rare, the disease is life threatening as it paralyzes the nerves (cranial nerve palsies) and subsequently affects respiratory muscles causing respiratory arrest and even death in some cases. The bacteria are normally found in untreated water, stools, and soil. However, when the bacterial spores (inactive forms) grow in favourable conditions (eg. small intestines), they cause grave danger to the individual.


The earliest recorded history of botulism was in 1735, when the disease was found to be associated with German sausage (foodborne illness). In 1870, a German physician by the name of Muller coined the term botulism from the Latin word for sausage. Clostridium botulinum bacteria were first isolated in 1895, and the neurotoxin that it releases was isolated in 1944 by Dr. Edward Schantz.

What are the Causes of Botulism?

Botulism arises due to toxins produced by the bacteria Clostridium botulinum. The bacteria produce spores or inactive forms of bacteria. Humans are infected in the following ways including

Food: When exposed to favourable conditions, the spores thrive in unhygenically manufactured foods, improperly handled food, or in food cooked at home. At home, food, such as carrot juice, cured ham and pork, oil containing chopped onions and garlic, honey, raw or smoked fish, can get contaminated.

Drugs: Individuals who inject themselves with recreational drugs, create a situation favourable to contamination with Clostridium bacteria.

Honey or Dirt: When infants have contaminated honey, use honey-contaminated pacifiers, or eat dirt, the bacterial spores reach and thrive in the small intestine.

What are the Five Types of Botulism?

There are five types of botulism:


What are the Symptoms and Signs of Botulism?

The signs and symptoms of botulism occur as nerve paralysis that sets in within a day to two days after consuming contaminated food. Sometimes, the symptoms set in quickly in 6 hours or may manifest only after 10 days. Wound injuries and infants tend to quickly get infected with the bacteria. There is no fever seen in this condition except in some cases of wound botulism.

The nerves in the eyes and face are affected by the bacterial toxin and become weak. The initial symptoms are:


Infants show the following symptoms:

Symptoms in advanced cases include:

The symptoms if left untreated could result in death to nearly 50% of patients. However, even with treatment, some people do not survive. In certain cases, hypotension (low blood pressure) is observed. In most cases, patients recover after a lengthy muscle paralysis and fatigue. Physical therapy helps to strengthen the muscles.

How can you Diagnosis of Botulism?

History and Physical Examination

The physician will take detailed history about food eaten in the past few days any wound sustained. He will examine the patient to assess for signs of muscle weakness such as drooping eyelids or a weak voice. However, some of the symptoms may be confused for other conditions.

Lab Tests

The physician will recommend laboratory tests of stool and blood samples. Laboratory testing (mouse bioassay) helps to confirm the presence and type of botulinum toxin involved.

Stool and Wound Cultures:

Patient's stool or wound cultures will help to differentiate between food poisoning caused by Cl botulinum and E coli, Salmonella spp or other Clostridium species e.g. Cl tetani. Wound culture showing Cl botulinum growth are suggestive of wound botulism.

Mouse Inoculation test:

The most definitive to confirm the diagnosis is to identify the botulinum neurotoxin in the patient's blood, serum, or stools. The patient's sample is injected into live mice. If the sample contained neurotoxin these animals will die. At the same time mice which have been given antitoxin will survive as the toxin will become neutralized

Miscellaneous tests - to rule out similar presenting conditions include:

How do you Treat Botulism?

There are different measures to treat botulism. If you are diagnosed with symptoms of botulism, you are admitted in the hospital for a considerable period. Treatment options include:

In C. botulinum-contaminated wounds, the tissue is removed surgically. Vomiting drugs or enema treatment, are prescribed to remove undigested food from the stomach.

Precautions during treatment

Equine-origin botulinum antitoxin is approved to treat all forms of botulism except infant botulism. Infants are treated with the botulism immune globulin antitoxin but not antibiotics. This helps to reduce the release of toxins into the intestine when antibiotics are given.

Antibiotics are not used in cases except wound botulism as they hasten release of toxin into bloodstream.

What are the Risk Factors of Botulism?

Based on how botulism is caused, we enlist the following as risk factors:

How can you Prevent Botulism?

References:

  1. About Botulism - (https://www.mayoclinic.org/diseases-conditions/botulism/symptoms-causes/syc-20370262)
  2. Sobel J. Diagnosis and treatment of botulism: A century later, clinical suspicion remains the cornerstone. Clin Inf Dis. 2009;Vol.48(12):1674-1675.
  3. Botulism. Updated Oct, 2014. Accessed June 4, 2018; Cited June 4, 2018.
  4. Sobel J, Rao AK. Making the best of the evidence: toward national clinical guidelines for botulism. Clin Inf Dis. 2018;Vol.66(Suppl_1):S1-S3.
  5. Information About Botulism - (https://www.cdc.gov/botulism/testing-treatment.html)
  6. Nigam PK, Nigam A. BOTULINUM TOXIN. Indian Journal of Dermatology. 2010;55(1):8-14. doi:10.4103/0019-5154.60343.
  7. Sobel J. Botulism. Clin Inf Dis. 2005;Vol.41(8):1167-1173.>

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