Symptoms and Signs of Parry-Romberg Syndrome

What are the Symptoms and Signs of Parry-Romberg Syndrome?

Symptoms of Parry-Romberg syndrome include:

• Atrophy (thinning or shrinkage) of the skin, soft tissues, muscle and in some cases cartilage and bone. The tissue degeneration occurs in the region of the face supplied by fifth cranial nerve (trigeminal nerve). This may result in sunken eyes or cheeks
• Hypoplasia or underdevelopment of a tissue or an organ

• Deviation of the nose or mouth towards the affected

  side

• Difficulty in opening and closing the jaws
• Malocclusion or abnormal appearance of teeth
• Deterioration of vision
• Hyperpigmentation or hypopigmentation
• Trigeminal neuralgia
• Facial hair may fall out or turn white
• Migraines
• Seizures
• Anxiety and depression

References:

1. Parry-Romberg Syndrome - National Organization for Rare Disorders (NORD) - (https://rarediseases.org/rare-diseases/parry-romberg-syndrome/)
2. Madasamy R Jayanandan M, Adhavan UR, Gopalakrishnan S, Mahendra L. Parry Romberg Syndrome: A Case Report and Discussion. J Oral Maxillofac Pathol. 2012; 16(3): 406-10. - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519218/)
3. Ortega VG, Sastoque D. New and Successful Technique for the Management of Parry-Romberg Syndrome�s Soft Tissue Atrophy. J Craniofac Surg. 2015; 26(6): e507-10. - (https://www.ncbi.nlm.nih.gov/pubmed/26335318)
4. Sargunar B, Ebenezer V, Balakrishnan R, Priya S. Parry Romberg Syndrome-A Review of Treatment Options. Biomed Pharmacol J. 2014; 7(1): 207-11. - (http://biomedpharmajournal.org/vol7no1/parry-romberg-syndrome-a-review-of-treatment-options/)
5. Wong M, Phillips CD, Hagiwara M, D.R. Shatzkes DR. Parry Romberg Syndrome: 7 Cases and Literature Review. Am J Neuroradiol. 2015; 36(7): 1355-61. - (http://www.ajnr.org/content/36/7/1355)