Complications and Prognosis of Epidermolysis Bullosa

Complications and Prognosis of Epidermolysis Bullosa

Junctional epidermolysis bullosis is associated with a high death rate, while other types of epidermolysis bullosa are milder and may not reduce life expectancy.


Complications of Epidermolysis Bullosa

• Anemia
• Narrowing of the food pipe (stricture)
• Eye disorders- Even blindness may ensue
• Infections- Pus forming bacteria or their toxins may lead to sepsis
• Functional loss of hands and feet
• Muscular dystrophy
• Dental disease
• Severe malnutrition
• Skin cancer: Epidermolysis bullosa can increase the risk of a type of skin cancer called squamous cell carcinoma

Prognosis of Epidermolysis Bullosa

The prognosis or outcome of epidermolysis bullosa depends upon the severity of the illness. Mild forms improve with age. Scarring left behind by blisters may lead to a number of complications.

• Contracture deformities could compromise mobility
• Involvement of mouth and food pipe causes difficulties with feeding and swallowing
• Secondary infections are not uncommon

References:

1. A.D.A.M Medical Encyclopedia
2. Vesicular and bullous diseases. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier;2009;chap 16.
3. Morelli JG. Vesiculobullous disorders. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 653.

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