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Male Infertility - Choromosomal Abnormalities

Medically Reviewed by The Medindia Medical Review Team on Nov 04, 2016


Chromosomal Abnormalities

Among men with azoospermia, the frequency of chromosomal abnormalities is estimated to be around 16%. Of these males 13% are found to have Klinefelter's syndrome and the remaining 3% have other chromosomal aberrations, such as ring Y chromosome and translocations.


5-6% of oligozoospermic men have karyotype anomalies which are mostly autosomal robertsonian and reciprocal translocations. In a recent study, sperm from men with extremely severe oligoasthenoteratozoospermia were found to have significantly higher frequency of aneuploidy and diploidy.

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