Complications and Prognosis of Gilbert�s syndrome
Complications and Prognosis of Gilbert's Syndrome
Enzyme deficiency in Gilbert's syndrome may lead to increased side effects of certain drugs. Prognosis is excellent.Complications
The jaundice produced by Gilbert's syndrome is mild. However, extremely elevated bilirubin levels may require drugs like phenobarbital.
The enzyme which is abnormal in Gilbert's syndrome is one that plays a role in clearing a number of medications in the body. Hence its deficiency (as in Gilbert's syndrome) may lead to increased side effects of certain drugs like:
- Irinotecan, a cancer chemotherapy drug - accumulation of the drug cause severe diarrhoea
- Indinavir: drug used in people with HIV infection
Prognosis (outlook) is excellent.
References:
- Harrison�s Principles of Internal Medicine 18th Edition
- The Merck Manual
- Cecil Medicine 24th Edition
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Dr. Nithin Jayan. (2014, September 03). Complications and Prognosis of Gilbert's syndrome. Medindia. Retrieved on Dec 20, 2024 from https://www.medindia.net/health/conditions/gilberts-syndrome-complications-and-prognosis.htm.
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Dr. Nithin Jayan. "Complications and Prognosis of Gilbert's syndrome". Medindia. Dec 20, 2024. <https://www.medindia.net/health/conditions/gilberts-syndrome-complications-and-prognosis.htm>.
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Dr. Nithin Jayan. "Complications and Prognosis of Gilbert's syndrome". Medindia. https://www.medindia.net/health/conditions/gilberts-syndrome-complications-and-prognosis.htm. (accessed Dec 20, 2024).
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Dr. Nithin Jayan. 2014. Complications and Prognosis of Gilbert's syndrome. Medindia, viewed Dec 20, 2024, https://www.medindia.net/health/conditions/gilberts-syndrome-complications-and-prognosis.htm.