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Septicemia / Sepsis - Causes and Risk Factors

Medically Reviewed by Dr. Nithin Jayan, MBBS, DNB on Sep 18, 2019


Causes and Risk Factors

People with decreased immunity are at a particular risk for developing sepsis.


Septicemia or sepsis is caused by bacteria, viruses or fungi. The infection is usually located in a particular tissue or organ and then spreads to the blood. The infection may also enter the body during an intravenous injection or a surgical procedure. People with decrease in immunity are unable to fight against the invading organisms and are particularly susceptible to sepsis. People at increased risk to develop sepsis include:

A number of cases of sepsis are caused by gram negative bacteria. These bacteria include E coli, Enterobacter, Klebsiella and Pseudomonas aeroginosa. Gram negative bacteria contain a component called lipopolysaccharide in their cell membrane. This part is particularly responsible for the effects of sepsis. Sepsis caused by gram negative bacteria especially Pseudomonas aeruginosa often has serious consequences including death.


References:

  1. Harrison�s Principles of Internal Medicine 17th edition.

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