Clinical features of von Willebrand's Disease

Clinical features of von Willebrand's Disease

von Willebrand disease is a congenital bleeding disorder and can be diagnosed at any age. Most patients with vWD have mild disease that may go undiagnosed until trauma or surgery occurs.

Symptoms include:

• Easy bruisability
• Mucosal surface bleeding: epistaxis (bleeding from the nose), gastrointestinal bleeding (bleeding from digestive tract), menorrhagia (Abnormally heavy or prolonged menstruation), bleeding of the gums
• Postoperative bleeding (particularly after tonsillectomy or tooth extractions)

Trauma, surgery, or tooth extractions may result in life-threatening bleeding in severely affected individuals

People with mild form of vWD may remain undiagnosed into adulthood. The use of drugs like aspirin or NSAIDs with anti-platelet effects may result in symptoms.

References:

1. Cecil Medicine, 23rd Ed.
2. Harrison's PRINCIPLES OF INTERNAL MEDICINE, 17^TH Edition

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