Macrolides are a large group of anti microbials derived from Streptomyces spp. With low toxicity exhibiting bacteriostatic and bactericidal(against some) effects through inhibition of bacterial RNA dependent protein synthesis by binding to 50S ribosomal subunit and some times manifesting cross resistance among them.
Thalidomide, a drug, which became notorious for Teratogenic abnormalities is now gaining to occupy a significant position in the therapeutic armamentarium of the physicians.
Zinc is a divalent cation exhibiting important role in health & disease as evidenced by the role of Zn in the functional capacity more than 200 metallic enzymes including Carbonic anhydrase, Carboxypeptidases, Alcohol dehydrogenases, Alkaline phophatases, and RNA Polymerases etc.,