Biochemistry Test

Test : 5 prime nucleotidase


Indications : The 5’-nucleotidase test is recommended for individuals experiencing the following symptoms or conditions:

1. Jaundice (yellowing of the skin and eyes)
2. Abdominal pain, particularly in the upper right quadrant
3. Fatigue or weakness
4. Itching (pruritus)
5. Dark urine or pale stools, indicating potential liver or biliary tract involvement

These symptoms suggest liver dysfunction, and the test helps in diagnosing conditions such as hepatitis, cirrhosis, or obstructive jaundice by assessing liver enzyme levels.

Physiology : 5'-Nucleotidase is an essential enzyme found in vertebrate tissues like the liver, kidneys, and intestines, playing a key role in metabolizing nucleotides. It breaks down nucleotides from their 5' end, ensuring efficient recycling and regulation of cellular nucleotide levels. Known for its ability to process a wide range of nucleotide types, the enzyme's activity in blood tests is pivotal for assessing liver function (1^✔ ✔Trusted Source
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases

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Normal Range : The normal range of a 5' nucleotidase test is 2-17 U/L (2^✔ ✔Trusted Source
5'-nucleotidase

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Interpretation : Increased level of 5 prime nucleotidase may indicate,

• Cirrhosis
• Cholestasis
• Heart disease
• Hepatitis
• Liver cancer
• Liver ischemia
• Liver necrosis
• Lung disease
• Ovarian cancer
• Pancreatic disease
• Rheumatoid arthritis

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