Conditions Associated with Increase in Fetal Hemoglobin

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Disease Conditions	Fetal Hemoglobin Values %
Aplastic anemia	5-25
Pernicious anemia	2-6
Hereditary Spherocytosis	2-5
Hereditary Elliptocytosis	2-5
Congenital anemia	3-4
Chronic infection anemia	2-3
Anemia due to blood loss	2-8
Erythropoietic Porphyria	2-10
Paroxysmal noctural hemoglobinuria	2-25
Unstable hemoglobins	<10
Homozygous HbS disease	<20
Hb Lepore trait	<5
Hb Kenya trait	6-13
B-thalassemia minor	25
db- thalassemia minor	5-20
b- thalassemia major	30-95
a-thalassemia minor	1
HbH disease	5-15
S/b - thalassemia	10-30
E/b - thalassemia	10-50
C/b - thalassemia	10-30
Hereditary persistence of Fetal hemoglobin (HPFH) - African type	15-40
HPFH - Greek type	10-20
HPFH - Swiss type	1-3

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