Ademetionine Medication Information
Get detailed information on Ademetionine, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.
The updated prescription information on Ademetionine provides an overview of possible side effects, precautions, warnings, and storage tips.
You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.
Generic Name : Ademetionine Pronunciation : Ade-met-ion-ine Therapeutic Classification : Anti- Inflammatory AgentsTrade Names/Brand Names of Ademetionine
India :
Hepa-Pro
Overview of Ademetionine
Ademetionine is also is called as S-adenosylmethionine.Why is Ademetionine Prescribed? (Indications)
Ademetionine is used for treating chronic liver disease such as intrahepatic cholestasis, a condition related to reduced bile flow resulting in accumulation. It is also used to treat mood disorders such as depression, osteoarthritis, and muscle pain or fibromyalgia.When should Ademetionine not be taken? (Contraindications)
• Ademetionine is contraindicated in patients with bipolar depression because of reports of increased anxiety and mania.• It should also not be used in patients allergic to the drug.
What is the dosage of Ademetionine?
Depression• Oral: 400-1600 mg per day
• IM/IV: 200-400 mg/day
Osteoarthritis
• Oral: 200 mg thrice daily
• IV: 400 mg/day
Liver Disease, Alcohol Related
• Oral: 1200-1600 mg per day; should not be administered for more than 2 years
• IV: 200-2000 mg/day for 15-30 days
• IM: 200 mg/day for 30 days
Intrahepatic Cholestasis
• Oral: 800 mg twice a day
Fibromyalgia
• 800 mg per day
How should Ademetionine be taken?
• Ademetionine tablets should be swallowed whole.• For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.
What are the warnings and precautions for Ademetionine?
• Caution is advised in patients with kidney disease.• Its use should be avoided in pregnancy especially in the first trimester; should be used only on the advice of a health care provider.
• It should also be avoided during breastfeeding.
What are the side effects of Ademetionine?
Gastrointestinal disorders: Vomiting, gas, constipation, diarrhea, loss of appetite, dry mouthNervous system disorders: Headache, insomnia, dizziness, nervousness
Serotonin syndrome: Symptoms include confusion, anxiety, tremors, diarrhea, high blood pressure and seizures
Others: Sweating, skin rashes, allergic reaction which could include anaphylactic reaction
What are the other precautions for Ademetionine?
• Ademetionine should be used under the supervision of a physician.• Folate and vitamin b12 deficiencies may decrease ademetionine levels; therefore patients at risk of these deficiencies should routinely check their vitamin B12 and folic acid level while taking ademetionine.
• Ademetionine should not be used in children and should be stopped at least two weeks before surgery.
• Ammonia levels should be monitored in patients with liver disease taking the medication.
What are the Drug Interactions of Ademetionine?
• Ademetionine can precipitate serotonin syndrome when administered with antidepressant drugs like fluoxetine, sertraline and clomipramine, monoamine oxidase inhibitors like phenelzine and tranylcypromine, and supplements like St.John's wort.• It should not be used in patients taking antidiabetes medication since it cause a severe reduction in blood sugar levels.
