Information about Cemiplimab-rwlc

Generic Name : Cemiplimab-rwlc
Up-to-date prescription details regarding Cemiplimab-rwlc are provided here.

Pronunciation : SEM-ip-LI-mab

Learn the correct pronunciation of the Cemiplimab-rwlc, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Cemiplimab-rwlc

India :

Libtayo

Why is Cemiplimab-rwlc Prescribed? (Indications)

Cemiplimab-rwlc is prescribed to treat cutaneous squamous skin cancer with tumors that are either locally advanced or that have moved to other body parts. It is used in patients who cannot be treated by radiation and surgery.

Cemiplimab-rwlc is a monoclonal antibody that blocks specific receptors and chemical pathways resulting in reduced immune response with subsequent tumor growth reduction.

Cutaneous squamous cell carcinoma is found to be the second most common form of skin cancer with more than 200,000 cases reported every year in the United States alone.

When should Cemiplimab-rwlc not be taken? (Contraindications)

Cemiplimab-rwlc should not be used in patients-

• If there is an allergy to cemiplimab-rwlc
• Pregnant and breastfeeding women
• Children

What is the dosage of Cemiplimab-rwlc?

The recommended adult dose of cemiplimab-rwlc is 350 mg for every three weeks.

The dose of cemiplimab-rwlc can either be reduced or the treatment can be permanently discontinued based on the severity of the side effects.

The treatment with cemiplimab-rwlc can be continued until the patient shows any progression of the disease or till the treatment with cemiplimab-rwlc does not result in intolerable toxicity.

How should Cemiplimab-rwlc be taken?

Cemiplimab-rwlc is available in a liquid form which should be given only by a healthcare provider as an intravenous infusion directly into the vein very slowly for at least 30 minutes.

The required amount of cemiplimab-rwlc to be injected should be diluted with 0.9% sodium chloride or 5 % dextrose solution and mixed by gentle inversion.

The vial and the diluted solution of cemiplimab-rwlc should be visually checked for any visible particles or coloration before injecting. The contents should be disposed of if such discoloration or changes occur.

What are the warnings and precautions for Cemiplimab-rwlc?

Women of childbearing age should be advised to use effective contraception during cemiplimab-rwlc treatment and should continue the contraception methods for at least four months after the last dose of cemiplimab-rwlc.
Breastfeeding mothers should be advised not to breastfeed their babies during the treatment and for at least four months after discontinuing cemiplimab-rwlc.
Patients must be advised to consult the doctor immediately if any symptoms and signs of the following occur-
- Hepatitis
- Nephritis
- Endocrinopathies (Thyroid disorders, Type 1 Diabetes, hypophysitis)
- Skin reactions (Rashes)
Monitoring liver and thyroid function along with blood parameters are necessary during the treatment and patients must be provided with proper medical care under the supervision of a specialist.
Pneumonitis can occur during the treatment with cemiplimab-rwlc and patients should be treated appropriately for any symptoms and signs of a severe cough, chest pain, and shortness of breath.
Patients should be advised to contact the doctor if any symptoms and signs of colitis such as loose stools, stomach pain, and presence of blood in stools occur.

What are the side effects of Cemiplimab-rwlc?

Gastrointestinal: Nausea, loose stools, constipation, loss of appetite, pancreatitis, stomach pain, blood in stools, colitis
Respiratory: Cough, chest pain, breathing difficulty, pneumonitis
Skin: Rash, itching, skin redness, mouth ulcers
Musculoskeletal: Muscle pain, back pain, neck pain, pain in the legs or hands
Lab abnormalities: Low levels of red blood cells, lymphocytes, albumin, sodium, calcium, and phosphate. High levels of liver enzymes
Others: Nephritis, thyroid disorders, type 1 diabetes, hypophysitis or swelling of the pituitary glands, liver damage, abnormal heartbeat, weakness

What are the other precautions for Cemiplimab-rwlc?

Extreme caution is required while cemiplimab-rwlc is given to the patients who undergo organ transplant or with a history of the following conditions-

• Breathing disorder
• Liver disease
• Kidney damage
• Diabetes
• Thyroid disorders
• Ulcerative colitis or Crohn’s disease

What are the Drug Interactions of Cemiplimab-rwlc?

Before taking cemiplimab-rwlc, patients must inform the doctor if they are taking or have a plan to take any prescription drugs, Over-The-Counter medications, or herbal supplements to avoid dangerous side effects.

What are the storage conditions for Cemiplimab-rwlc?

Store cemiplimab-rwlc vials in the refrigerator at 2°C and 8°C.

Protect the vials from light, excess heat and moisture.

Do not shake or freeze the vial or the diluted solution of cemiplimab-rwlc.

The diluted solution of cemiplimab-rwlc can be used for up to 8 hours if stored at room temperature between 20°C and 25°C. If stored in a refrigerator at 2°C to 8°C, the diluted solution of cemiplimab-rwlc should be used within 24 hours.