Delamanid Medication Information

Discover comprehensive details about Delamanid, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Delamanid brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Delamanid

Therapeutic Classification : Anti- Tuberculosis

Brand Names or Trade Names of Delamanid

India :

Deltyba

Overview of Delamanid

Delamanid, a nitroimidazole drug was approved for use in combination with bedaquiline for treating multidrug-resistant or extensively drug-resistant tuberculosis.

Why is Delamanid Prescribed? (Indications)

Delamanid is an anti-tubercular drug prescribed in combination with bedaquiline for treating active multidrug-resistant tuberculosis in adults when other treatments fail or show no response.

Delamanid works by interfering with the synthesis of bacterial cell wall components leading to loss of rigidity and resulting in cell death.

When should Delamanid not be taken? (Contraindications)

Delamanid should not be used in patients with-

• Allergy to delamanid
• Pregnancy and breastfeeding
• Low levels of albumin (less than 2.8g/dl)

Patients taking medicines that are strong inducers of CYP3A4
• Carbamazepine
• Phenytoin
• Rifampin
• Rifabutin
• Nevirapine
• Rifapentine
• Primidone

Children below 18 years of age as the safety and efficacy of delamanid are not established.

What is the dosage of Delamanid?

• The dose of delamanid for adults is 100 mg which should be taken two times daily for 24 weeks.

• Delamanid must be given as part of the combination regimen and should be followed with the appropriate treatment schedule according to WHO guidelines.

• Delamanid is recommended to be given by directly observed therapy (DOT).

How should Delamanid be taken?

• Delamanid is available as a tablet which should be taken by mouth with food to avoid gastric comfort.

What are the warnings and precautions for Delamanid?

• Patients should be monitored for cardiac function as delamanid can result in alterations in the cardiac rhythm.

• It is advised to obtain an ECG before starting treatment with delamanid and every following month until the full course of treatment is completed.

• Levels of albumin should be monitored during treatment with delamanid as cases of hypoalbuminemia have been reported.

• Blood parameters should be monitored for detecting abnormalities of potassium, calcium, and magnesium electrolyte levels.

• Women of childbearing age should use effective contraceptive measures before starting treatment with delamanid.

What are the side effects of Delamanid?

Common: A headache, dizziness, nausea, vomiting, muscle pain, asthenia or weakness
Gastrointestinal: Pain in the stomach, gastritis, constipation, indigestion
Cardiovascular: Abnormal heart rhythm, increased or decreased blood pressure, hematoma
Blood: Reticulocytosis, anemia, eosinophilia
Nervous system: Anxiety, depression, restlessness, agitation, drowsiness
Respiratory: Difficulty in breathing, cough, pain and irritation of the throat, runny nose
Skin: Dermatitis, hyperhidrosis, pruritus, rashes, urticaria, acne
Others: Blood in urine, fever, chest pain, dry eyes, earache

What are the other precautions for Delamanid?

• Follow the treatment schedule strictly to gain more benefit.
• Liver function should be evaluated before, during, and after the treatment.
• Treatment of overdose should be treated by removing delamanid from the gastrointestinal tract, and by providing supportive care.

What are the Drug Interactions of Delamanid?

Avoid using delamanid with the following drugs that increase the cardiac rhythm.

• Anti-arrhythmic drugs (e.g., amiodarone, quinidine, sotalol)
• Antipsychotics (e.g., chlorpromazine, haloperidol, fluphenazine)
• Anti-retrovirals (e.g., lopinavir, ritonavir, efavirenz)
• Anti-fungals (e.g., itraconazole, fluconazole, voriconazole)
• Antidepressants (e.g., amitriptyline, imipramine)
• Moxifloxacin
• Ethambutol
• Domperidone

What are the storage conditions for Delamanid?

• Store in the original container at room temperature below 25° C.
• Protect from excess heat and moisture.
• Keep the tablets out of reach of children.