Doripenem Medication Information

Discover comprehensive details about Doripenem, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Doripenem brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Doripenem

Pronunciation : dor i PEN em

ICD Code : Y40.1 Therapeutic Classification : Antibiotics

Brand Names or Trade Names of Doripenem

India :

Icupen, Sudopen.

International :

Doribax

Why is Doripenem Prescribed? (Indications)

This medication is an antibiotic that fights bacteria. It is used to treat severe infections of the stomach (complicated intra-abdominal infections), bladder, or kidneys (pyelonephritis) and infections caused by designated susceptible bacteria.

When should Doripenem not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity, anaphylactic reactions to beta-lactams.

What is the dosage of Doripenem?

Complicated intra-abdominal infections: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 5-14 days; may switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement.
Complicated urinary tract infections: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 10 days, and can be extended up to 14 days for patients with concurrent bacteraemia.
Pyelonephritis: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 10 days, and can be extended up to 14 days for patients with concurrent bacteraemia.
Nosocomial pneumonia: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 or 4 hr (Infections with less susceptible pathogens may use 4-hr infusion).

How should Doripenem be taken?

It comes as a solution for injection, administered by a healthcare provider.

What are the warnings and precautions for Doripenem?

• Caution should be exercised in patients with history of kidney impairment, seizures, pregnant and breast feeding women, children and elderly.

• May cause development of drug-resistant bacteria when used in the absence of proven or strongly suspected bacterial infection.

• Take full course of treatment as directed by your physician.

• When doripenem is inhaled, it causes pneumonitis. Hence avoid taking this medication through inhalation.

What are the side effects of Doripenem?

Central Nervous System - Headache.
Heart - Vein inflammation.
Gastrointestinal - Nausea, diarrhea.
Blood - Anemia, low number of white blood cells, decreased platelet count in blood.
Genitourinary - Kidney impairment, vaginal itching or discharge.
Skin - Itching, rash, hives, toxic epidermal necrolysis.
Infection - Oral candidiasis.
Respiratory - Difficulty in breathing.
General - Swelling of face, lips, tongue, or throat.
Lab Tests - Increased levels of hepatic enzymes.
Hypersensitivity - Stevens-Johnson Syndrome.