Fosphenytoin Medication Information
Get detailed information on Fosphenytoin, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.
The updated prescription information on Fosphenytoin provides an overview of possible side effects, precautions, warnings, and storage tips.
You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.
Generic Name : Fosphenytoin Pronunciation : fos-FEN-i-toin ICD Code : Y46.2 Therapeutic Classification : AnticonvulsantsTrade Names/Brand Names of Fosphenytoin
India :
International :
Cerebyx
Why is Fosphenytoin Prescribed? (Indications)
This medication is an anticonvulsant, prescribed for seizures during neurosurgery and status epilepticus. It works in the brain to block the spread of seizure activity.When should Fosphenytoin not be taken? (Contraindications)
Contraindicated in patients with history of allergic reaction to similar drugs, abnormalities in heart rhythm and Adams-Stokes syndrome.What is the dosage of Fosphenytoin?
IV/IM- Tonic-clonic status epilepticus- As phenytoin Na equivalents (PSE)- Loading dose: 15 mg PSE /kg via IV infusion.Maintenance: Initial: 4-5 mg PSE/kg/day, subsequent doses depend on patient's response and trough-plasma phenytoin levels.
Seizures except status epilepticus- As PSE: Loading dose: 10-15 mg/kg. Maintenance: Initial: 4-5 mg/kg/day; subsequent doses depend on patient's response and trough-plasma phenytoin levels.
How should Fosphenytoin be taken?
It comes as a solution for injection, to be administered by a healthcare provider into the vein or muscle.What are the warnings and precautions for Fosphenytoin?
•It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.• Caution should be exercised in patients with history of heart problem, liver or kidney disease, low blood albumin levels, diabetes, alcoholism, elderly, patients requiring phosphate restriction.
• Resuscitation facilities must be available.
• Monitor ECG, BP, blood sugar, and respiratory function during infusion; observe patients for at least 30 minutes after infusion.
• IV infusion rate should not exceed 150 mg PSE/minute in adults or 3 mg PSE/kg/minute in children ≥5 yr.
What are the side effects of Fosphenytoin?
Heart- Low blood pressure, dilatation of blood vessels and fast heart beat.Central Nervous System- Involuntary eye movement, dizziness, drowsiness, unsteadiness, tremor, headache, incoordination, stupor, weakness, increase in muscle tone, abnormal movements, tingling, agitation, decreased reflexes, brain edema, speech disorder, sensory loss, vertigo, abnormal thinking, increased reflexes, intracranial hypertension and nervousness.
Skin- Itching, face edema, rash.
Eye and ENT- perception of sound within the human ear in the absence of corresponding external sound. Double vision, taste perversion, blurred vision and deafness.
Gastrointestinal- Nausea, dry mouth, tongue disorder, vomiting and constipation.
Blood- Easy bruising.
Skin- Injection-site pain.
Metabolic- Low potassium in blood.
Musculoskeletal- Back pain and muscle weakness.
Respiratory- Pneumonia.
Miscellaneous- Pelvic pain, chills, fever, infection and fetal defects during pregnancy.
