Ledipasvir and Sofosbuvir Medication Information

Get detailed information on Ledipasvir and Sofosbuvir, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

The updated prescription information on Ledipasvir and Sofosbuvir provides an overview of possible side effects, precautions, warnings, and storage tips.

You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.

Generic Name : Ledipasvir and Sofosbuvir

Trade Names/Brand Names of Ledipasvir and Sofosbuvir

India :

Harvoni

Why is Ledipasvir and Sofosbuvir Prescribed? (Indications)

The ledipasvir and sofosbuvir combination is used in the treatment of chronic Hepatitis C infection (A viral infection which causes severe damage to the liver) with genotype 1,4, 5 and 6. Sofosbuvir and ledipasvir are antiviral medications that belong to nucleotide polymerase inhibitors and HCV NS5A inhibitor groups, respectively. The drugs prevent the multiplication of the virus.

The combination is sometimes prescribed along with another antiviral drug ribavirin.

When should Ledipasvir and Sofosbuvir not be taken? (Contraindications)

The ledipasvir and Sofosbuvir combination should not be used in patients who are allergic to the drugs, or with the use of prescription medicines or nutritional supplements that may cause side effects.

What is the dosage of Ledipasvir and Sofosbuvir?

The recommended dose of the combination includes ledipasvir 90mg and sofosbuvir 400mg to be taken once daily for a period of 8 to 24 weeks based on the patient’s condition and the genotype of the hepatitis C virus.

How should Ledipasvir and Sofosbuvir be taken?

The combination comes in the form of a tablet to be taken orally by mouth either with food or on an empty stomach.

What are the warnings and precautions for Ledipasvir and Sofosbuvir?

• The combination of ledipasvir and sofosbuvir should not be prescribed along with amiodarone as far as possible. If these drugs have to be prescribed together, cardiac monitoring is required. Patients who experience a decrease in heart rate must consult the doctor immediately.

• The combination of ledipasvir and sofosbuvir along with ribavirin is contraindicated during pregnancy.

What are the side effects of Ledipasvir and Sofosbuvir?

General: Tiredness
Gastrointestinal: Nausea, diarrhea
Central Nervous System: Headache, sleeping difficulties.

What are the other precautions for Ledipasvir and Sofosbuvir?

• The ledipasvir and sofosbuvir combination could result in reactivation of hepatitis B infection. Therefore, all patients who are going to receive the combination should be screened for either current or prior hepatitis B infection.

What are the Drug Interactions of Ledipasvir and Sofosbuvir?

Ledipasvir and Sofosbuvir combination should be avoided with:

Antiarrhythmic Drugs:

Amiodarone or digoxin when taken with ledipasvir and sofosbuvir combination may slow down the heart and increase the risk of heart arrest. The use of the drugs together should therefore be avoided.

Anticonvulsant Drugs:

Phenytoin, carbamazepine, phenobarbital might reduce the concentration and decrease the efficacy of ledipasvir and sofosbuvir combination.

Antitubercular Agents:

Rifampin and rifabutin decrease the concentration of the ledipasvir and sofosbuvir drug combination and thereby reduce the efficacy of the drug.

HMG CoA Reductase Inhibitors:

The ledipasvir and sofosbuvir combination increases the concentration of rosuvastatin and may increase the risk of rhabdomyolysis (breakdown of skeletal muscle).

Antacids:

Antacid preparations containing aluminium hydroxide or magnesium hydroxide interfere with the absorption of ledipasvir and are therefore taken either four hours before or after the ledipasvir and sofosbuvir drug combination.

Simprenevir:

Concomitant administration of another Hepatitis C drug simprenevir should be avoided with the ledipasvir and sofosbuvir drug combination since the concentration of both simprevevir and ledipasvir can increase.

Anti-HIV medications:

Consult the doctor before taking HIV antiretroviral drugs like tenofovir, cobicistat and elvitegravir with the ledipasvir and sofosbuvir drug combination as there could be a drug interaction.