Information about Mercaptopurine

Generic Name : Mercaptopurine
Up-to-date prescription details regarding Mercaptopurine are provided here.

Pronunciation : mer kap toe pyoor' een

Learn the correct pronunciation of the Mercaptopurine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y43.1 Therapeutic Classification : Antimetabolites

Trade Names/Brand Names of Mercaptopurine

India :

More info >>>

International :

Purinethol.

Why is Mercaptopurine Prescribed? (Indications)

This medication is an antimetabolite, prescribed for acute lymphatic leukemia either alone or with other medications. It works by stopping the growth of cancer cells.

When should Mercaptopurine not be taken? (Contraindications)

Contraindicated in patients who have prior resistance to this drug, and hypersensitivity.

What is the dosage of Mercaptopurine?

Adult: PO- Acute lymphatic Leukemia: Usual maintenance dose: Initial: 1.5-2.5 mg/kg/day, may increase carefully up to 5 mg/kg/day.
Crohn's disease Initial: 1-1.5 mg/kg/day. Up to 125 mg/day.

How should Mercaptopurine be taken?

It comes as a tablet to take by mouth, on an empty stomach.

What are the warnings and precautions for Mercaptopurine?

• Caution should be exercised in patients with history of bone marrow problems, anemia, low white blood cell or platelet levels, unusual bruising or bleeding, liver or kidney problems, infections, any allergy, during pregnancy and breastfeeding.

• Avoid contact with people who have infections.

• It may reduce platelet counts; to prevent bleeding avoid injury or bruising.

• Patient may develop with increased risk other than cancer; if any unusual tumor appears consult with your doctor immediately.

• Avoid vaccination while taking this medication.

• Monitor blood cell counts, liver function tests, and TPMT enzyme activity regularly while taking this medication.

What are the side effects of Mercaptopurine?

Serious Effects - Bone marrow depression and liver damage.
Genitourinary - Abnormally elevated blood level of uric acid.
Gastrointestinal - Intestinal ulceration, nausea, vomiting, and loss of appetite.
Miscellaneous - Hair loss and decrease in sperm count.