Methyldopa - Indications, Dosage, Side Effects and Precautions

Information about Methyldopa

Generic Name : Methyldopa
Up-to-date prescription details regarding Methyldopa are provided here.

Pronunciation : meth ill doe' pa

Learn the correct pronunciation of the Methyldopa, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y51.8 Therapeutic Classification : Anti- Adrenergic Blockers - Centrally Acting

Trade Names/Brand Names of Methyldopa

India :

International :

Aldochlor 250, Aldoril

Why is Methyldopa Prescribed? (Indications)

This medication is an alpha-2 receptor agonist, prescribed for hypertension.  It reduces elevated blood pressure by dilating blood vessels.

When should Methyldopa not be taken? (Contraindications)

Contraindicated in patients with liver disease, on therapy with monoamine oxidase (MAO) inhibitors, and hypersensitivity.

What is the dosage of Methyldopa?

Adult- The usual initial dose is 250 mg two or three times a day in the first 48 hours. Maintenance: 500mg to gm in divided doses.
Child- Initial dosage is based on 10 mg/kg of body weight daily in two to four doses.

How should Methyldopa be taken?

It comes as a tablet and liquid to take by mouth, with or without food.

What are the side effects of Methyldopa?

Heart - Aggravation of chest pain, heart failure, sinus hypersensitivity, low blood pressure, swelling or weight gain and slow heart rate.
Gastrointestinal - Inflammation of intestine/pancreas/ mouth, vomiting, diarrhea, sore or "black" tongue, nausea, constipation, distension, flatulence and dryness of mouth.
Blood - Bone marrow depression.
Liver - Liver inflammation, jaundice and abnormal liver function.
Hypersensitivity - Inflammation of heart muscle, blood vessels, lupus-like syndrome, drug-related fever and eosinophilia.
Central Nervous System - Parkinson’s disease, Bell's palsy, decreased mental acuity, involuntary movements, mild psychoses or depression, headache, sleepiness, weakness, dizziness, lightheadedness and tingling.
Metabolic - Rise in Blood Urea Nitrogen.
Musculoskeletal - Joint pain/swelling and muscle pain.
Respiratory - Nose stuffiness.
Skin - Skin damage and rash.
Genitourinary - Absence of menstrual periods, breast enlargement in male, spontaneous secretion of milk, impotence and decreased libido.

What are the other precautions for Methyldopa?

Avoid excess dosage.

What are the storage conditions for Methyldopa?

Store it in a well-closed container at controlled room temperature (15-30°C).