Nusinersen Medication Information

Get detailed information on Nusinersen, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

The updated prescription information on Nusinersen provides an overview of possible side effects, precautions, warnings, and storage tips.

You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.

Generic Name : Nusinersen

Trade Names/Brand Names of Nusinersen

India :

Spinraza

Why is Nusinersen Prescribed? (Indications)

Nusinersen is a survival motor neuron (SMN-2) directed antisense oligonucleotide which is prescribed for the treatment of spinal muscular atrophy (SMA) in children and adults.

Spinal muscular atrophy is a genetic disease which affects the nervous system and causes weakness of muscles under voluntary control. Oligonucleotides are small strands of DNA or RNA that can bind to specific molecules of RNA. Nusinersen increases the production of SMN protein, which is deficient in these patients.

When should Nusinersen not be taken? (Contraindications)

Currently, there are no definite contraindications to the use of nusinersen.

What is the dosage of Nusinersen?

The dose of nusinersen injection is 12mg (5ml) per administration. The first three doses should be administered at 14-day intervals, and the fourth dose should be given 30 days after the third dose. One dose should be repeated every four months thereafter.

How should Nusinersen be taken?

Nusinersen injection is injected intrathecally (into the backbone) over 1-3 minutes so that it reaches the cerebrospinal fluid (CSF), the fluid that bathes the brain and the spinal cord.

What are the warnings and precautions for Nusinersen?

• Allow the injection to come to room temperature before the administration.

• The solution must be injected within four hours of removal from the vial.

• A total of 5ml of cerebrospinal fluid has to be removed prior to the administration of injection.

• Monitor the platelet count, coagulation profile, and urine protein before beginning treatment and before each dose of the medication.

What are the side effects of Nusinersen?

Respiratory System: Respiratory tract infections, difficulty in breathing
Blood: Reduced platelet count, problems with blood clotting
Kidneys: Possible kidney damage
ENT: Ear infection
Gastrointestinal System: Constipation
Central Nervous System: Scoliosis (sideways curving of the spine).

What are the other precautions for Nusinersen?

• Nusinersen injection may increase the risk of bleeding. Therefore it is essential to perform blood tests for platelet count and clotting at the baseline before each dose of the drug to monitor for early signs.
• Do not administer the injection if there is a presence of any particular matter or discoloration.
• Check the urine for protein for any indication of renal toxicity