Information about Posaconazole

Generic Name : Posaconazole
Up-to-date prescription details regarding Posaconazole are provided here.

Pronunciation : POE-sa-KON-a-zole

Learn the correct pronunciation of the Posaconazole, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Trade Names/Brand Names of Posaconazole

International :

Noxafil. National-Poscosafe, Picasa, Posanal

Overview of Posaconazole

Posaconazole is indicated for preventing and treating fungal infections like aspergillosis, oropharyngeal (mouth and throat) candidiasis. These infections are common in people with very low immunity. Recently there is increase usage of Posaconazole for black fungus or mucormycosis in COVID-19 positive cases.

Why is Posaconazole Prescribed? (Indications)

Posaconazole is indicated for preventing fungal infections like aspergillosis, candidiasis. It is also used for treating mucormycosis or black fungus and, oropharyngeal (mouth and throat) candidiasis Aspergillosis
Candidiasis
Mucormycosis

When should Posaconazole not be taken? (Contraindications)

• Allergic to Posaconazole
• Pregnant women
• Lactating women

What is the dosage of Posaconazole?

Posaconazole is available as injection containing 18mg per mL. 100 mg delayed-release tablets are also available.
Oral suspension is available in 123 mL containing 40 mg of posaconazole per mL

How should Posaconazole be taken?

Injection: Loading dose for aspergillosis: 300 mg injection given into vein twice a day on the first day. Then, 300 mg injection into vein once a day.
Delayed-Release Tablets: 300 mg tablets twice a day on the first day and 300 mg once a day from the second day.
Take Noxafil delayed-release tablets with food. Oral Suspension: 200 mg (5 mL) three times a day. Shake oral suspension properly before use.
Take each dose during or within 20 minutes after a full meal Do not switch between taking delayed-release tablets and oral suspension. In patients with oropharyngeal candidiasis, Posaconazole can be given for 14 days. For prevention of aspergillosis, duration depends on immunity.

Missed a Dose?

Patients should take it as soon as they remember. Skin the dose if it is less than 12hours due for the next dose. Patients should not double their next dose or take more than the prescribed dose.

What are the warnings and precautions for Posaconazole?

• Caution is required in patients with a history of electrolyte disturbances, diarrhea, vomiting, liver, kidney, or heart problems, who are taking other medications, any allergy, during pregnancy, and breastfeeding.

• It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.

• It does not cure viral or bacterial infections.

• Avoid long-term use of this medication; otherwise, it may cause the secondary infection.

• Monitor blood sugar, liver function, and heart function regularly while taking this medication.

• Extreme caution is needed for children less than 13 years old.

What are the side effects of Posaconazole?

Most Common - Gl disorders, specifically, nausea, vomiting, and increased levels of liver enzymes.
Body as a Whole - Fever, headache, rigors, fatigue, swelling in the legs, loss of appetite, dizziness, fluid retention, weakness.
Heart - High blood pressure and low blood pressure.
Blood - Anemia, decrease in white blood cells.
Genitourinary - Vaginal bleeding.
Gastrointestinal - Diarrhea, nausea, vomiting, abdominal pain, constipation, indigestion.
Heart - Fast heart rate.
Infection - Inflammation of pharynx, upper respiratory tract infection.
Liver - Bilirubinemia.
Metabolic - Increase or decrease in blood minerals.
Musculoskeletal - Muscle and joint pain, back pain.
Blood - Decrease in platelet counts.
Central Nervous System - Sleeplessness and anxiety.
Respiratory - Coughing, difficulty in breathing, nosebleed.
Skin - Rash and itching.

What are the other precautions for Posaconazole?

Avoid excess dosage.

What are the Drug Interactions of Posaconazole?

Do not take posaconazole with
: • Sirolimus
• Pimozide
• Quinidine
• HMG-CoA Reductase Inhibitors like statins
• Ergot alkaloids

What are the storage conditions for Posaconazole?

Store Posaconazole injection in refrigerator at 2 to 8 o C. Delayed release tablets and oral suspension at 20-25°C

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