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Protamine Sulphate - Indications, Dosage, Side Effects and Precautions

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Protamine Sulphate Medication Information

Learn everything you need to know about Protamine Sulphate-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it.

Get up-to-date information on side effects, precautions, warnings, and proper storage to ensure safe usage.

Explore Protamine Sulphate brand names commonly used in India and internationally, along with detailed pricing information. Consult your healthcare provider for tailored medical advice.

Generic Name : Protamine Sulphate
Pronunciation : PRO-tuh-meen SULL-fate
Therapeutic Classification : Heparin Antagonists

Brand Names or Trade Names of Protamine Sulphate

India :

International :


Protamine Sulfate

Why is Protamine Sulphate Prescribed? (Indications)

This medication is a heparin antagonist, prescribed for reversing the anticoagulant effects of heparin.

When should Protamine Sulphate not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Protamine Sulphate?

IV- 1 mg for each 90 units of heparin derived from lung tissue or 115 units of heparin derived from intestinal mucosa.

How should Protamine Sulphate be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Protamine Sulphate?

• Caution should be exercised in patients with history of poor blood circulation, heparin rebound, lung swelling, any allergy, children, during pregnancy and breastfeeding.

• Avoid too much rapid application.

• Monitor prothrombin time regularly while taking this medication.

What are the side effects of Protamine Sulphate?

Heart - Low blood pressure, slow heart rate, and circulatory collapse.
Central Nervous System - Lassitude.
Gastrointestinal - Nausea and vomiting.
Respiratory - Shortness of breath, lung swelling and acute pulmonary hypertension.
Miscellaneous - Severe respiratory distress, poor blood circulation, noncardiogenic lung swelling; transient flushing and feeling of warmth and back pain.

What are the other precautions for Protamine Sulphate?

Avoid excess dosage.

What are the storage conditions for Protamine Sulphate?

Store it at controlled room temperature (15 and 30°C). Do not freeze.

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