Prothionamide - Indications, Dosage, Side Effects and Precautions

Information about Prothionamide

Generic Name : Prothionamide
Up-to-date prescription details regarding Prothionamide are provided here.

Pronunciation : Pro-thion-amide

Learn the correct pronunciation of the Prothionamide, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Anti- Tuberculosis

Trade Names/Brand Names of Prothionamide

India :

Other Name(s) of Prothionamide

Protionamide

Overview of Prothionamide

Prothionamide is a thioamide that forms an important component in multidrug-resistant tuberculosis treatment regimens in adults and children.

Why is Prothionamide Prescribed? (Indications)

Prothionamide is prescribed to treat multidrug-resistant tuberculosis (MDR TB) and given as part of a treatment regime, usually involving 5 medicines.

It is also used to treat tuberculous meningitis in adults and children.

Prothionamide is a thioamide, structurally similar to ethionamide and clinically interchangeable with it.

When should Prothionamide not be taken? (Contraindications)

• Prothionamide is contraindicated in patients with known allergy to the drug.

• Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.

What is the dosage of Prothionamide?

The recommended dose for prothionamide is

Adults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg

How should Prothionamide be taken?

• Prothionamide should be taken orally.

• Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.

• The dose can be split into two if once a day dose is not tolerated.

• Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.

• Take with or after meals to reduce gastrointestinal adverse effects.

What are the side effects of Prothionamide?

Gastrointestinal:Excessive salivation, metallic taste, nausea, vomiting, abdominal pain, anorexia, diarrhea and inflammation of the mouth
Central nervous system: Depression, drowsiness, encephalopathy, peripheral neuropathy, headache, restlessness, anxiety, psychotic disturbances
Liver: Transient increases in Liver Function Test parameters, acute hepatitis (rare)
Metabolic: Hypothyroidism, gynecomastia, hypoglycemia

What are the other precautions for Prothionamide?

• Thyroid function tests have to be taken once in 3 months when taking prothionamide.

• Blood sugar levels must be monitored in diabetic patients.

What are the Drug Interactions of Prothionamide?

Prothionamide could cause adverse effects when given along with

• Cycloserine (increased risk of neurotoxicity).
• Isoniazid (increased serum concentrations).
• P-aminosalicylic acid (increased risk of hypothyroidism).
• Rifampicin and thiacetazone (increased risk of hepatotoxicity).

What are the storage conditions for Prothionamide?

Prothionamide should be stored at room temperature.